Tertiary S-Nitrosothiol Functionalized Mesoporous Silica Nanoparticles for Nitric Oxide Delivery

IF 5.5 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2025-09-19 DOI:10.1021/acsanm.5c03029

Rajnish Kumar, , , Tsian D. Ramrattan, , and , Mark H. Schoenfisch*,

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引用次数: 0

Abstract

The exogenous delivery of nitric oxide (NO) as a therapeutic is challenging due to NO’s high reactivity and short half-life. Owing to NO’s many physiological functions, the development of NO-releasing materials for sustained and long-term NO delivery has been a focus of much research. Herein, we report the synthesis of an organosilane bestowing a tertiary thiol (3° SH) moiety derived from (3-aminopropyl)trimethoxysilane and N-acetyl-d-penicillamine thiolactone (NAP-thiolactone). The resulting tertiary thiol-bearing organosilanes (NAPTMS) were covalently tethered to mesoporous silica nanoparticles (MSNs) to generate 3° SH-enriched MSNs (MSN-NAP) that, when nitrosated, formed NO-releasing mesoporous silica nanoparticles (MSN-SNAP). The morphological and thermomechanical properties of MSN-NAP and MSN-SNAP proved suitable as potential therapeutic materials, with NO payloads (1.39 ± 0.15 μmol mg^–1) approximately ten times greater than previously reported tertiary S-nitrosothiol (3° RSNO) systems. In contrast to other reports, MSN-SNAP exhibits a sustained NO-release profile for >24 h under physiological conditions. The MSN-SNAP thus represents a promising NO-releasing prodrug for various biomedical applications that require sustained NO delivery at low concentrations (pM to nM).

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叔s -亚硝基硫醇功能化介孔二氧化硅纳米颗粒用于输送一氧化氮

由于一氧化氮（NO）的高反应性和短半衰期，外源性递送作为治疗是具有挑战性的。由于一氧化氮具有多种生理功能，开发能够持续和长期释放一氧化氮的释放材料一直是研究的热点。本文报道了一种由（3-氨基丙基）三甲氧基硅烷和n -乙酰-d-青霉胺硫内酯（ap -硫内酯）合成的具有叔硫醇（3°SH）片段的有机硅烷。所得到的含叔硫醇的有机硅烷（NAPTMS）与介孔二氧化硅纳米颗粒（MSNs）共价连接，生成3°sh富集的MSNs (MSN-NAP)，当亚硝化时，形成释放no的介孔二氧化硅纳米颗粒（MSN-SNAP）。mnn - nap和mnn - snap的形态学和热力学性能证明，其NO有效载荷（1.39±0.15 μmol mg-1）约为先前报道的叔s -亚硝基硫醇（3°RSNO）体系的10倍。与其他报道相反，MSN-SNAP在生理条件下表现出持续24小时的no释放特征。因此，MSN-SNAP代表了一种有前途的一氧化氮释放前药，适用于各种需要低浓度（pM至nM）持续释放一氧化氮的生物医学应用。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.