From form to function: New heights in kidney organoids

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-10-02 DOI:10.1016/j.stem.2025.09.003

Jonathan Levinsohn, Katalin Susztak

引用次数: 0

Abstract

In this issue of Cell Stem Cell, Huang et al.¹ address the challenge of creating organoids that more closely replicate kidney spatial patterning and function. They develop region-specific progenitor assembloids mimicking native architecture. After transplantation into mice, which further promotes differentiation, they demonstrate functional and disease modeling capability.

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从形态到功能：肾类器官的新高度

在这一期的《细胞干细胞》中，Huang等人1解决了创造更接近复制肾脏空间模式和功能的类器官的挑战。他们开发了模仿本地建筑的特定区域的祖组合体。在移植到小鼠体内后，进一步促进分化，显示出功能和疾病建模能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.