Toward a thermodynamic taxonomy of amyloid fibrils

IF 4.3 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Structure Pub Date : 2025-10-02 DOI:10.1016/j.str.2025.08.010

Nikolaos Louros, Joost Schymkowitz, Frederic Rousseau

引用次数: 0

Abstract

In this issue of Structure, Connor et al.¹ combine topology and residue-level energetics of α-synuclein and tau fibrils to identify isoenergetic fold families. They reveal how conserved hotspot residues, mutations, and, potentially, environmental cues steer polymorph selection, providing a unified framework for comparing amyloid strains and classifying emergent structures.

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淀粉样原纤维的热力学分类

在本期《Structure》中，Connor等人将α-突触核蛋白和tau原纤维的拓扑结构和残基水平能量学结合起来，确定了等能折叠家族。他们揭示了保守的热点残基、突变和潜在的环境因素如何引导多态性选择，为比较淀粉样蛋白菌株和分类紧急结构提供了统一的框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Structure 生物-生化与分子生物学

CiteScore

8.90

自引率

1.80%

发文量

155

审稿时长

3-8 weeks

期刊介绍： Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding, and/or design, will also be considered. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single-molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure-activity relationships and will not consider studies that solely report structural information unless the structure or analysis is of exceptional and broad interest. Studies reporting only homology models, de novo models, or molecular dynamics simulations are also discouraged unless the models are informed by or validated by novel experimental data; rationalization of a large body of existing experimental evidence and making testable predictions based on a model or simulation is often not considered sufficient.