Multifunctional self-healing hydrogels for chronic wound repair: Design, mechanisms, and applications

IF 11.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of Controlled Release Pub Date : 2025-10-02 DOI:10.1016/j.jconrel.2025.114282

Xuyang Ning , Hong Lu , Huiying Zeng , Ziqiang Zhou , Ping Hu

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引用次数: 0

Abstract

Chronic wounds arise from a multifactorial interplay involving persistent hyperglycemia, recurrent infection, tissue ischemia, and sustained inflammation, which collectively disrupt cellular metabolic homeostasis, impair angiogenesis and extracellular matrix remodeling, ultimately leading to impaired healing progression. Multifunctional self-healing hydrogels have become promising biomaterials to solve these problems due to their excellent biocompatibility, self-healing ability and multiple functional properties. These hydrogels can autonomously restore their structure and function after injury, thus maintaining the therapeutic effect of the wound site. In addition, they exhibit multifunctional properties, including antimicrobial activity, adhesion, hemostasis, anti-inflammatory and antioxidant effects, drug delivery, promotion of angiogenesis and nerve repair, electrical conductivity, and monitoring capabilities, resulting in significantly improved wound healing outcomes. In this paper, the healing process and current status of chronic wounds are first discussed, and then the latest progress in the preparation mechanism, functional properties and mechanical properties of multifunctional self-healing hydrogels is studied. The application of these hydrogels in chronic wound healing is critically analyzed, with a focus on their self-healing mechanisms and functional properties，and it is worth emphasizing the first comprehensive analysis of the hydrogels' function in neurovascular regeneration. In addition, the design related to clinical translation is also discussed. Future research directions are proposed, including the development of smart hydrogels and the exploration of new biomaterials to provide more innovative and effective solutions for chronic wound management. Overall, multifunctional self-healing hydrogels represent a transformative approach to chronic wound healing with great potential for clinical applications.

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用于慢性伤口修复的多功能自愈水凝胶：设计、机制和应用

慢性伤口的产生是多因素相互作用的结果，包括持续高血糖、反复感染、组织缺血和持续炎症，这些因素共同破坏细胞代谢稳态，损害血管生成和细胞外基质重塑，最终导致愈合进程受损。多功能自愈水凝胶以其优异的生物相容性、自愈能力和多种功能特性成为解决这些问题的理想生物材料。这些水凝胶可以在损伤后自主恢复其结构和功能，从而保持伤口部位的治疗效果。此外，它们还具有多种功能，包括抗菌活性、粘附、止血、抗炎和抗氧化作用、药物传递、促进血管生成和神经修复、电导率和监测能力，从而显著改善伤口愈合结果。本文首先讨论了慢性伤口的愈合过程和现状，然后对多功能自愈水凝胶的制备机理、功能特性和力学性能的最新进展进行了研究。批判性地分析了这些水凝胶在慢性伤口愈合中的应用，重点研究了它们的自愈机制和功能特性，值得强调的是首次全面分析了水凝胶在神经血管再生中的功能。此外，还讨论了与临床翻译相关的设计。提出了未来的研究方向，包括智能水凝胶的开发和新型生物材料的探索，为慢性伤口管理提供更多创新和有效的解决方案。总之，多功能自愈水凝胶代表了一种具有巨大临床应用潜力的慢性伤口愈合的变革性方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.