{"title":"Distribution and variations of anti-müllerian hormone (AMH) levels among poor-responder women: a multiple linear regression analysis.","authors":"Parvin Hakimi, Fatemeh Tabatabaei, Roya Ghaffari, Fatemeh Kazemi Namin, Hosein Azizi, Roya Kabodmehri, Mahshid Alborzi","doi":"10.1186/s40834-025-00402-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Anti-Mullerian hormone (AMH) is an indicator of a woman's ovarian reserve or the number of follicles remaining in her ovaries. While the level of AMH is typically low among poor responders, there is significant variation in its levels among poor responders.</p><p><strong>Objective: </strong>This study aimed to investigate the AMH level in poor-responder women and examine its association with nutrition, lifestyle, and reproductive characteristics.</p><p><strong>Methods: </strong>A total of 119 infertile women with poor-responder were randomly selected from the infertility clinic of Al-Zahra Hospital, Tabriz, in 2022. Clinical, lifestyle, and reproductive characteristics were measured using valid instruments and para-clinical tests. Multiple linear regression analysis was carried out to estimate the variations of AMH level among poor-responder women.</p><p><strong>Results: </strong>The average age of the participants was 36.6, and a significant negative correlation was found between advanced age and AMH level (r = -0.35, P = 0.001). In the final analysis, after adjusting for potential confounders using multiple linear regression, each unit increase in age, passive smoking, the cold season, poor or no vegetable consumption, and poor physical activity resulted in a decrease in AMH level by -0.162, -0.123, -0.321, -0.199, and - 0.212, respectively.</p><p><strong>Conclusion: </strong>Findings indicated that lifestyle and nutrition are correlated with AMH levels in infertile women with poor responder. Promoting a healthy lifestyle can improve ovarian reserve in these women with with low level of AMH.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":93956,"journal":{"name":"Contraception and reproductive medicine","volume":"10 1","pages":"63"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12487047/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contraception and reproductive medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s40834-025-00402-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
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Abstract
Background: Anti-Mullerian hormone (AMH) is an indicator of a woman's ovarian reserve or the number of follicles remaining in her ovaries. While the level of AMH is typically low among poor responders, there is significant variation in its levels among poor responders.
Objective: This study aimed to investigate the AMH level in poor-responder women and examine its association with nutrition, lifestyle, and reproductive characteristics.
Methods: A total of 119 infertile women with poor-responder were randomly selected from the infertility clinic of Al-Zahra Hospital, Tabriz, in 2022. Clinical, lifestyle, and reproductive characteristics were measured using valid instruments and para-clinical tests. Multiple linear regression analysis was carried out to estimate the variations of AMH level among poor-responder women.
Results: The average age of the participants was 36.6, and a significant negative correlation was found between advanced age and AMH level (r = -0.35, P = 0.001). In the final analysis, after adjusting for potential confounders using multiple linear regression, each unit increase in age, passive smoking, the cold season, poor or no vegetable consumption, and poor physical activity resulted in a decrease in AMH level by -0.162, -0.123, -0.321, -0.199, and - 0.212, respectively.
Conclusion: Findings indicated that lifestyle and nutrition are correlated with AMH levels in infertile women with poor responder. Promoting a healthy lifestyle can improve ovarian reserve in these women with with low level of AMH.
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