Yuyang Gan, Jiarui Zhang, Fangfang Qi, Elizabeth A Grice, Luis A Garza, Gaofeng Wang
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引用次数: 0
Abstract
The human skin serves as a major reservoir of mutualists that penetrate skin appendages and contribute to skin development, barrier repair, appendage health, and wound healing. The skin microbiota exhibits significant shifts in community composition in response to pathological skin conditions, such as impaired barrier integrity, follicular-sebaceous-related diseases, and wound healing, which contribute to the progression of skin diseases. Crosstalk among bacteria, fungi, and viruses and their collective effects on the host are critical determinants of skin health and disease. This review discusses the changes in the skin microbiota under both physiological and pathological conditions, with a particular focus on bacterial strains, virulence factors, and pathogenic genes, and their impact on host outcomes. Additionally, we preview the emerging clinical applications of specific bacterial strains, microbial competition, fungal cooperation, phage therapy, and engineered microbial interventions.
期刊介绍：
Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically.
Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.
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