LIFE-Moms: effects of multicomponent lifestyle randomized control trial on physical activity during pregnancy in women with overweight and obesity.

IF 5.5 1区医学 Q1 NUTRITION & DIETETICS

International Journal of Behavioral Nutrition and Physical Activity Pub Date : 2025-09-30 DOI:10.1186/s12966-025-01805-9

Hannah E Cabre, Kimberly L Drews, Jeremy Pomeroy, Sarah Kozey Keadle, S Sonia Arteaga, Paul W Franks, Debra Haire-Joshu, William C Knowler, Xavier Pi-Sunyer, Linda Van Horn, Rena R Wing, Alison G Cahill, Rebecca G Clifton, Kimberly A Couch, Dympna Gallager, Jami L Josefson, Kaumudi Joshipura, Samuel Klein, Corby K Martin, Alan M Peaceman, Suzanne Phelan, Elizabeth A Thom, Leanne M Redman

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引用次数: 0

Abstract

Background: This report details the effect of LIFE-Mom's multicomponent lifestyle interventions on physical activity (PA) and inactivity time across pregnancy (2nd and 3rd trimesters) and their effect on gestational weight gain (GWG) and maternal/neonatal outcomes, a pre-specified secondary analysis.

Methods: Pregnant people with BMI ≥ 25 kg/m² were randomized to lifestyle interventions with dietary and PA counseling or standard care. PA and inactivity time measured by accelerometry and metabolic and inflammatory biomarkers measured in fasting blood are reported in 522 pregnant people at baseline and end of pregnancy. Generalized linear models with and without covariates were used to evaluate group differences (intervention vs. control) and, separately, time differences (total sample with both groups combined).

Results: Although there were statistically significant differences in vigorous activity between the intervention and control group (p = .024), there were no clinically meaningful differences in PA. In the combined sample, moderate to vigorous PA (MVPA) significantly decreased across pregnancy (mean ± SD: 72.9 ± 29.1 min/day vs 63.9 ± 28.1 min/day; p < 0.0001), and inactivity time increased [617.5 min/day (573.5, 659.6) vs 630.4 min/day (56.7, 679.9); p < 0.0001]. Increased inactivity time was associated with a less favorable maternal milieu (biomarker Z-scores) for pro-inflammatory (0.2 ± 0.1; p = 0.003) and cardiometabolic markers (0.1 ± 0.07; p = 0.030).

Conclusions: Physical activity declined over the course of pregnancy, though the intervention group experienced a smaller reduction in activity levels. Our results linked increased inactivity time to maternal metabolic dysregulation and inflammation. Further research is needed to determine if intensive interventions reducing inactivity can improve maternal health and weight outcomes in pregnant people with overweight and obesity.

Trial registration: NCT01545934, NCT01616147, NCT01771133, NCT01631747, NCT01768793, NCT01610752, and NCT01812694.

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生活-妈妈：多组分生活方式随机对照试验对超重和肥胖妇女怀孕期间身体活动的影响。

背景：本报告详细介绍了LIFE-Mom的多组分生活方式干预对妊娠期间（第二和第三个月）身体活动（PA）和不活动时间的影响，以及它们对妊娠体重增加（GWG）和孕产妇/新生儿结局的影响，这是一项预先指定的次要分析。方法：将BMI≥25 kg/m2的孕妇随机分为饮食和PA咨询或标准护理的生活方式干预组。在522名孕妇的基线和妊娠结束时，通过加速计测量PA和不活动时间，在空腹血液中测量代谢和炎症生物标志物。采用带协变量和不带协变量的广义线性模型来评估组间差异（干预组与对照组），并单独评估时间差（两组合并的总样本）。结果：干预组与对照组在剧烈运动方面差异有统计学意义（p = 0.05）。024)， PA无临床意义差异。在联合样本中，中度至剧烈PA （MVPA）在整个妊娠期间显著下降（平均±SD: 72.9±29.1分钟/天vs 63.9±28.1分钟/天）；p结论：体力活动在妊娠期间下降，尽管干预组的活动水平下降幅度较小。我们的研究结果将不活动时间的增加与母体代谢失调和炎症联系起来。需要进一步的研究来确定减少不活动的强化干预措施是否可以改善孕产妇健康和超重和肥胖孕妇的体重结局。试验注册号：NCT01545934、NCT01616147、NCT01771133、NCT01631747、NCT01768793、NCT01610752、NCT01812694。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Behavioral Nutrition and Physical Activity 医学-生理学

CiteScore

13.80

自引率

3.40%

发文量

138

审稿时长

4-8 weeks

期刊介绍： International Journal of Behavioral Nutrition and Physical Activity (IJBNPA) is an open access, peer-reviewed journal offering high quality articles, rapid publication and wide diffusion in the public domain. IJBNPA is devoted to furthering the understanding of the behavioral aspects of diet and physical activity and is unique in its inclusion of multiple levels of analysis, including populations, groups and individuals and its inclusion of epidemiology, and behavioral, theoretical and measurement research areas.