Selective serotonin reuptake inhibitors enhance cancer immunosurveillance by pleiotropic mechanisms.

IF 6.5 2区医学 Q1 IMMUNOLOGY

Oncoimmunology Pub Date : 2025-12-31 Epub Date: 2025-09-30 DOI:10.1080/2162402X.2025.2564734

Karla Alvarez-Valadez, Guido Kroemer, Mojgan Djavaheri-Mergny

引用次数: 0

Abstract

In a recent paper published in Cell, Li et al. suggest that selective serotonin reuptake inhibitors (SSRIs) antidepressants act on serotonin transporters on CD8⁺ T cells to enhance antitumor immunity. Beyond this mechanism, SSRIs can act on malignant cells, as well as on other immune cells, to improve cancer immunosurveillance.

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选择性血清素再摄取抑制剂通过多效机制增强癌症免疫监测。

在最近发表于Cell的一篇论文中，Li等人提出，选择性5 -羟色胺再摄取抑制剂（SSRIs）抗抑郁药作用于CD8+ T细胞上的5 -羟色胺转运体，以增强抗肿瘤免疫。除此之外，SSRIs还可以作用于恶性细胞，以及其他免疫细胞，以提高癌症免疫监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncoimmunology ONCOLOGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

12.50

自引率

2.80%

发文量

276

审稿时长

24 weeks

期刊介绍： OncoImmunology is a dynamic, high-profile, open access journal that comprehensively covers tumor immunology and immunotherapy. As cancer immunotherapy advances, OncoImmunology is committed to publishing top-tier research encompassing all facets of basic and applied tumor immunology. The journal covers a wide range of topics, including: -Basic and translational studies in immunology of both solid and hematological malignancies -Inflammation, innate and acquired immune responses against cancer -Mechanisms of cancer immunoediting and immune evasion -Modern immunotherapies, including immunomodulators, immune checkpoint inhibitors, T-cell, NK-cell, and macrophage engagers, and CAR T cells -Immunological effects of conventional anticancer therapies.