Absence of Macrolide-Resistant Mutations in Bordetella pertussis in Antananarivo (Madagascar) and Cambodia During the Last Pertussis Cycle Before the COVID-19 Pandemic.

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2025-09-29 eCollection Date: 2025-10-01 DOI:10.1093/ofid/ofaf566

Florence Campana, Mahdi Rajabizadeh, Mallorie Hide, Gauthier Delvallez, Samrach Han, Lala Rafetrarivony, Bunnet Dim, Aina Harimanana, Gaelle Noel, Mohand Ait-Ahmed, Jean-Marc Collard, Laurence Borand, Nicole Guiso, Fabien Taieb

引用次数: 0

Abstract

Macrolides are the first-line treatment against pertussis. The high prevalence of macrolide-resistant Bordetella pertussis (MRBP) strains reported in China is concerning. MBRP might be underestimated in other countries. Looking for the mutation causative for MRBP in retrospective studies conducted in Madagascar and Cambodia, we found no MRBP.

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在2019冠状病毒病大流行前的最后一个百日咳周期中，塔那那利佛（马达加斯加）和柬埔寨的百日咳杆菌未发现大环内酯类耐药突变

大环内酯类药物是治疗百日咳的一线药物。据报道，耐大环内酯百日咳（MRBP）菌株在中国的高流行率令人担忧。MBRP在其他国家可能被低估了。在马达加斯加和柬埔寨进行的回顾性研究中寻找导致MRBP的突变，我们没有发现MRBP。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.