COXFA4L3 enhances mitochondrial complex IV function to boost ATP synthesis and drive sperm motility.

IF 4.5 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2025-09-28 DOI:10.1016/j.mito.2025.102082

Reiji Tokito, Kosei Oishi, Tomoya Sugiyama, Yusuke Fujisawa, Fujino Kuba, Kaito Yoshida, Kaoru Yoshida, Manabu Yoshida, Yoichiro Tanaka, Taku Amo, Noritaka Yamaguchi, Taishin Akiyama, Yuji Imai, Kazuto Yoshimi, Tsuyoshi Koide, Yasuyuki Kurihara

引用次数: 0

Abstract

COXFA4L3 is a testis-specific cytochrome c oxidase subunit that enhances mitochondrial complex IV activity during spermatogenesis. From the analysis of Coxfa4l3 knockout mice, the isoform switch from COXFA4 to COXFA4L3 may increase the potential COX activity, although this activity does not appear in the testis. This latent enhancement becomes evident in sperm, where COXFA4L3 promotes higher respiratory capacity, increasing sperm motility and ATP production. These findings indicate that COXFA4L3 is a key regulator of mitochondrial energy metabolism and may provide insights into the mechanisms underlying male infertility.

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COXFA4L3增强线粒体复合体IV功能，促进ATP合成，驱动精子活力。

COXFA4L3是睾丸特异性细胞色素c氧化酶亚基，在精子发生过程中增强线粒体复合体IV活性。从敲除Coxfa4l3小鼠的分析来看，从COXFA4到Coxfa4l3的异构体转换可能会增加潜在的COX活性，尽管这种活性并未出现在睾丸中。这种潜在的增强在精子中变得明显，其中COXFA4L3促进更高的呼吸能力，增加精子活力和ATP的产生。这些发现表明，COXFA4L3是线粒体能量代谢的关键调节因子，并可能为男性不育的机制提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.