CPMOAD: comprehensive preeclampsia multi-omics analysis database.

IF 7.5 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of Translational Medicine Pub Date : 2025-09-30 DOI:10.1186/s12967-025-07094-x

Yang Fang, Mengzhe Fan, Hao Li, Hongen Xu, Hongmei Du, Yaqing Guo, Jinshuang Gao, Erfeng Yuan, Liying Song, Yu Wang, Qianqian Shi, HaiYang Yu, Enwu Yuan, Xin Zhao, Linlin Zhang

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引用次数: 0

Abstract

Background: Preeclampsia (PE) is a pregnancy-specific syndrome that poses serious risks to both maternal and fetal health globally. Despite the accumulation of multi-omics datasets from various studies, a unified platform that integrates these resources for comprehensive analysis remains unavailable.

Methods: We developed CPMOAD (Comprehensive Preeclampsia Multi-Omics Analysis Database), an online platform designed to integrate RNA-seq, DNA methylation, and literature-curated data related to PE. All datasets were uniformly processed to generate differential expression profiles, methylation data, and curated molecular interaction records. The database is equipped with interactive visualization tools and customizable analysis modules.

Results: CPMOAD offers access to a broad spectrum of PE-relevant data, including gene expression and methylation profiles. Users can perform differential expression analysis, methylation analysis, and pathway enrichment analysis directly through the web interface. The platform also enables the exploration of validated molecular signatures associated with PE.

Conclusions: CPMOAD serves as a comprehensive and user-friendly resource for integrated multi-omics analysis in preeclampsia research. By consolidating diverse datasets and providing powerful analytical tools, CPMOAD aims to accelerate the discovery of molecular mechanisms and potential biomarkers for PE. The database is freely accessible at http://nscc.zzu.edu.cn/CPMOAD/ .

查看原文本刊更多论文

CPMOAD：综合子痫前期多组学分析数据库。

背景：子痫前期（PE）是一种妊娠特异性综合征，在全球范围内对孕产妇和胎儿健康构成严重风险。尽管从各种研究中积累了多组学数据集，但整合这些资源进行综合分析的统一平台仍然不可用。方法：我们开发了CPMOAD（综合子痫前期多组学分析数据库），这是一个在线平台，旨在整合RNA-seq、DNA甲基化和与PE相关的文献整理数据。对所有数据集进行统一处理，生成差异表达谱、甲基化数据和整理的分子相互作用记录。该数据库配备了交互式可视化工具和可定制的分析模块。结果：CPMOAD提供了广泛的pe相关数据，包括基因表达和甲基化谱。用户可以通过web界面直接进行差异表达分析、甲基化分析和途径富集分析。该平台还可以探索与PE相关的经过验证的分子特征。结论：CPMOAD是子痫前期综合多组学分析的一个全面且用户友好的资源。通过整合不同的数据集和提供强大的分析工具，CPMOAD旨在加速发现PE的分子机制和潜在的生物标志物。该数据库可在http://nscc.zzu.edu.cn/CPMOAD/免费访问。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Translational Medicine 医学-医学：研究与实验

CiteScore

10.00

自引率

1.40%

发文量

537

审稿时长

1 months

期刊介绍： The Journal of Translational Medicine is an open-access journal that publishes articles focusing on information derived from human experimentation to enhance communication between basic and clinical science. It covers all areas of translational medicine.