Investigation of the potential of phytochemicals derived from citrus peels to inhibit digestive enzymes: an overture to the management of lifestyle diseases.

IF 5.4 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Enzyme Inhibition and Medicinal Chemistry Pub Date : 2025-12-01 Epub Date: 2025-10-01 DOI:10.1080/14756366.2025.2564800

Lebohang Moloi, Sana Samson, Kadima Tshiyoyo, Kamogelo Maluleke, Marni Oberholzer, Itumeleng Baloyi, Samkelo Malgas

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引用次数: 0

Abstract

The food industry relies on citrus fruits for juice, canned fruit, and jam, creating significant waste from peels, seeds, and pomace. This waste contains valuable phytochemicals like carotenoids, essential oils, (poly)phenols, pectin, and vitamins, which can be used as nutraceuticals or key ingredients in functional foods for managing diabetes and obesity. Repurposing citrus peel waste offers an excellent opportunity to advance biorefineries and the bioeconomy. Compounds derived from citrus have attracted attention for their potential therapeutic effects on diabetes and obesity, and their effectiveness depends on various mechanisms. This review summarises citrus-derived phytochemicals that inhibit α-glucosidase and pancreatic lipase in vitro, highlighting their potential as anti-diabetic and anti-obesity compounds. We also discuss progress in using molecular docking screening against key drug targets linked to type II diabetes and obesity. This review explores novel citrus phytochemicals for the development of nutraceuticals and functional food ingredients with enhanced health benefits.

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从柑橘皮中提取的植物化学物质抑制消化酶的潜力的研究：对生活方式疾病管理的序曲。

食品工业依赖于柑橘类水果的果汁、罐头水果和果酱，产生了大量的果皮、种子和果渣。这些废物含有有价值的植物化学物质，如类胡萝卜素、精油、（多）酚、果胶和维生素，它们可以用作营养品或用于控制糖尿病和肥胖的功能性食品的关键成分。柑橘皮废料的再利用为推进生物炼制和生物经济提供了一个极好的机会。柑橘类化合物因其对糖尿病和肥胖症的潜在治疗作用而备受关注，其疗效取决于多种机制。本文综述了柑橘来源的植物化学物质在体外抑制α-葡萄糖苷酶和胰脂肪酶的研究，重点介绍了它们作为抗糖尿病和抗肥胖化合物的潜力。我们还讨论了利用分子对接筛选与2型糖尿病和肥胖相关的关键药物靶点的进展。本文综述了柑橘类植物化学物质在营养保健品和功能性食品成分开发中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Enzyme Inhibition and Medicinal Chemistry 医学-生化与分子生物学

CiteScore

10.30

自引率

10.70%

发文量

195

审稿时长

4-8 weeks

期刊介绍： Journal of Enzyme Inhibition and Medicinal Chemistry publishes open access research on enzyme inhibitors, inhibitory processes, and agonist/antagonist receptor interactions in the development of medicinal and anti-cancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry aims to provide an international and interdisciplinary platform for the latest findings in enzyme inhibition research. The journal’s focus includes current developments in: Enzymology; Cell biology; Chemical biology; Microbiology; Physiology; Pharmacology leading to drug design; Molecular recognition processes; Distribution and metabolism of biologically active compounds.