The association between digestion-resistant and bioactive peptide content of dairy products and bladder cancer: a case-control study.

IF 2.8 3区医学 Q3 ENVIRONMENTAL SCIENCES

Journal of Health, Population, and Nutrition Pub Date : 2025-09-30 DOI:10.1186/s41043-025-01071-2

Atiyeh Sadat Hosseini, Seyyed Mostafa Jalali, Zainab Shateri, Marzieh Shoja, Milad Rajabzadeh-Dehkordi, Maede Makhtoomi, Melika Hajjar, Bahram Rashidkhani, Mehran Nouri

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引用次数: 0

Abstract

Background: Bladder cancer is the sixth most common cancer worldwide. Bioactive peptides (BP) are digestion-resistant (enzymatically stable) and absorbable fragments that exert physiological functions in the body. We conducted this case-control study to examine the association between dairy-derived BPs and bladder cancer.

Methods: The present case-control study (103 cases and 200 controls) was a hospital-based investigation conducted in three referral hospitals in Tehran, Iran. Dietary intake was assessed using a validated 168-item Food Frequency Questionnaire (FFQ). Intake of BPs was estimated based on dairy product consumption recorded in the FFQ. Logistic regression analysis was used to examine the association between the content of digestion-resistant BPs in dairy products and the odds of bladder cancer.

Results: After adjusting confounding factors, it was observed that the odds of bladder cancer were significantly lower in the second and last tertiles (T) of total peptide intake from dairy products compared to the first tertile (T₂: odds ratio (OR) = 0.285; 95% confidence interval (CI): 0.116-0.699, T₃: OR = 0.130; 95% CI: 0.032-0.527). Additionally, in the adjusted model, a significant inverse association was found between other dairy-derived peptides and the odds of bladder cancer.

Conclusions: The findings suggest a potential inverse relationship between milk-derived BPs and bladder cancer risk, which warrants further investigation in longitudinal or interventional studies. However, further studies are needed to elucidate the biological properties and mechanism of action of milk-derived BPs.

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乳制品中抗消化和生物活性肽含量与膀胱癌之间的关系：一项病例对照研究。

背景：膀胱癌是全球第六大常见癌症。生物活性肽（BP）是抗消化（酶稳定）和可吸收的片段，在体内发挥生理功能。我们进行了这项病例对照研究，以检查乳制品来源的bp与膀胱癌之间的关系。方法：本病例对照研究（103例和200例对照）是在伊朗德黑兰的三家转诊医院进行的以医院为基础的调查。膳食摄入量评估采用经验证的168项食物频率问卷（FFQ）。bp的摄入量是根据FFQ中记录的乳制品消费量来估计的。采用Logistic回归分析来检验乳制品中抗消化bp含量与膀胱癌发病率之间的关系。结果：在调整混杂因素后，观察到从乳制品中摄取总肽的第二和最后三分位数(T)与第一分位数相比，膀胱癌的发生率显著降低(T2：优势比(OR) = 0.285；95%置信区间（CI）： 0.116-0.699, T3: OR = 0.130；95% ci: 0.032-0.527)。此外，在调整后的模型中，发现其他乳制品衍生肽与膀胱癌的几率呈显著负相关。结论：研究结果提示牛奶源性bp与膀胱癌风险之间存在潜在的负相关关系，值得在纵向或介入性研究中进一步研究。然而，乳源性bp的生物学特性和作用机制有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Health, Population, and Nutrition 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Journal of Health, Population and Nutrition brings together research on all aspects of issues related to population, nutrition and health. The journal publishes articles across a broad range of topics including global health, maternal and child health, nutrition, common illnesses and determinants of population health.