Clinical Study on the Effects of Modified Hupo San on Reproductive Hormone Levels and Microcirculation in Patients with Menstrual Disorders of Cold Congelation and Blood Stasis Pattern.
{"title":"Clinical Study on the Effects of Modified Hupo San on Reproductive Hormone Levels and Microcirculation in Patients with Menstrual Disorders of Cold Congelation and Blood Stasis Pattern.","authors":"Ran Ma, Na Zhang, Juan Xing, Yan Wang, Xi Zhen","doi":"10.2147/IJWH.S539135","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of Modified Hupo San on reproductive hormone levels and microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern.</p><p><strong>Methods: </strong>A total of 102 patients from the gynecological outpatient department of our hospital were randomly assigned into a control group (n=51) and a study group (n=51). Randomization was performed using a computer-generated random number table The study group was treated with Modified Hupo San for 3 cycles, while the control group received routine therapy. Blood samples were collected on the 2nd day of menstruation before treatment and again on the 2nd day of the 4th cycle. Serum levels of TXB2, 6-keto-PGF1α, t-PA, PAI-1, estradiol (E2), and progesterone (P) were measured. Safety monitoring was performed throughout the study. Statistical analysis was conducted using SPSS 22.0, with t-tests and chi-square tests applied, and P<0.05 considered statistically significant.</p><p><strong>Results: </strong>The total effective rate of Modified Hupo San in treating menstrual disorders of cold congelation and blood stasis pattern was 96.30%. Compared with baseline, serum TXB2 and PAI-1 levels significantly decreased, while 6-keto-PGF1α, t-PA, and t-PA/PAI-1 ratio significantly increased after treatment in the study group. E2 levels significantly increased after treatment, and were higher than those in the control group (P<0.05). Progesterone showed no significant difference.</p><p><strong>Conclusion: </strong>Modified Hupo San demonstrated significant therapeutic effects in improving reproductive hormones and regulating microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern, with good safety.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"3271-3278"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478210/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Women's Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/IJWH.S539135","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To investigate the effects of Modified Hupo San on reproductive hormone levels and microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern.
Methods: A total of 102 patients from the gynecological outpatient department of our hospital were randomly assigned into a control group (n=51) and a study group (n=51). Randomization was performed using a computer-generated random number table The study group was treated with Modified Hupo San for 3 cycles, while the control group received routine therapy. Blood samples were collected on the 2nd day of menstruation before treatment and again on the 2nd day of the 4th cycle. Serum levels of TXB2, 6-keto-PGF1α, t-PA, PAI-1, estradiol (E2), and progesterone (P) were measured. Safety monitoring was performed throughout the study. Statistical analysis was conducted using SPSS 22.0, with t-tests and chi-square tests applied, and P<0.05 considered statistically significant.
Results: The total effective rate of Modified Hupo San in treating menstrual disorders of cold congelation and blood stasis pattern was 96.30%. Compared with baseline, serum TXB2 and PAI-1 levels significantly decreased, while 6-keto-PGF1α, t-PA, and t-PA/PAI-1 ratio significantly increased after treatment in the study group. E2 levels significantly increased after treatment, and were higher than those in the control group (P<0.05). Progesterone showed no significant difference.
Conclusion: Modified Hupo San demonstrated significant therapeutic effects in improving reproductive hormones and regulating microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern, with good safety.
期刊介绍：
International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
