Immune-Related Peripheral Keratopathy in Post-COVID-19 Syndrome.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
International Medical Case Reports Journal Pub Date : 2025-09-25 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S539734
Bingxu Chen, Xiyun Li, Lei Qu, Shuduan Wu
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引用次数: 0

Abstract

Background: Post-COVID-19 Syndrome, marked by systemic immune dysregulation, has been linked to various ocular manifestations, including conjunctivitis, anterior uveitis, and vitritis. Emerging evidence highlights the role of inflammatory mediators, cytokines, and abnormal immune cell activation in post-viral complications, which may contribute to corneal damage. This case report describes immune-related peripheral keratopathy in a patient with Post-COVID-19 Syndrome, emphasizing that it may influence the ocular surface immune microenvironment.

Case presentation: We describe a woman in her 30s who has a history of mild dry eye disease. After her third COVID-19 infection, she experienced eye redness, dryness, and a foreign body sensation. Ophthalmic examination revealed a corneal ulcer at the limbal region in both eyes. Treatment with topical antibiotics, corticosteroids, anti-inflammatory agents, and lubricating eye drops, led to substantial improvement and complete healing within two months.

Conclusion: Systemic immune dysregulation following COVID-19 infection may alter the ocular surface immune microenvironment, thereby predisposing patients to ocular surface complications.

Abstract Image

Abstract Image

covid -19综合征后免疫相关性外周角膜病变
背景:以全身免疫失调为特征的covid -19后综合征与多种眼部表现有关,包括结膜炎、前葡萄膜炎和玻璃体炎。新出现的证据强调了炎症介质、细胞因子和异常免疫细胞激活在病毒后并发症中的作用,这可能导致角膜损伤。本病例报告描述了一例covid -19后综合征患者的免疫相关性周围角膜病变,强调其可能影响眼表免疫微环境。病例介绍:我们描述了一位30多岁的女性,她有轻度干眼症的病史。在第三次感染COVID-19后,她出现了眼睛发红、干燥和异物感。眼科检查发现双眼边缘区有角膜溃疡。局部使用抗生素、皮质类固醇、抗炎药和润滑眼药水治疗,导致明显改善,并在两个月内完全愈合。结论:COVID-19感染后全身免疫失调可能改变眼表免疫微环境,从而使患者易发生眼表并发症。
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来源期刊
International Medical Case Reports Journal
International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
135
审稿时长
16 weeks
期刊介绍: International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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