Multiple paragangliomas diagnosed in head, neck, and mediastinum: a case report.

IF 2.3 3区 医学 Q2 PATHOLOGY
Shahab Rafieian, Hesam Amini, Omid Rezaei, Aysan Nozheh, Niloofar Ayoobi Yazdi
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引用次数: 0

Abstract

Background: Paragangliomas are neuroendocrine tumors that often present as solitary tumors. In this case report, we describe a patient with multiple head and neck paraganglioma associated with a mediastinal paraganglioma.

Case presentation: The patient was a 46-year-old male with a history of surgical removal of a mass from the right side of the neck, who presented with dysphonia lasting two months, hoarseness, vague chest pain, and unilateral ptosis. CT angiography of the carotid arteries and thoracic aorta revealed multiple findings, including a well-defined enhancing mass measuring 33 × 39 mm in the aorto-pulmonary prevascular space, a grade I carotid body tumor on the left side of the neck, vagal paragangliomas on the right side of the neck, and a glomus jugulare tumor on the right side. These findings were collectively suggestive of multiple paragangliomas. The patient subsequently underwent surgical resection of the mediastinal tumor, and pathological examination confirmed the diagnosis of paraganglioma.

Conclusion: This report details a rare case of paraganglioma with multiple head, neck, and mediastinal involvement, emphasizing the need for thorough evaluation and genetic assessment in atypical presentations.

头颈部及纵隔多发副神经节瘤1例。
背景:副神经节瘤是一种神经内分泌肿瘤,常表现为孤立性肿瘤。在这个病例报告中,我们描述了一个患者多发性头颈部副神经节瘤合并纵隔副神经节瘤。病例介绍:患者为46岁男性,曾手术切除颈部右侧肿块,表现为发音困难持续两个月,声音嘶哑,胸痛模糊,单侧上睑下垂。颈动脉及胸主动脉CT血管造影显示多发病灶,包括主动脉-肺血管间隙一明显强化肿块,大小为33 × 39 mm,左侧颈动脉体1级肿瘤,右侧颈迷走副神经节瘤,右侧颈静脉球瘤。这些发现共同提示多发性副神经节瘤。患者随后行纵隔肿瘤手术切除,病理检查证实为副神经节瘤。结论:本报告详细介绍了一例罕见的副神经节瘤伴多发性头颈部和纵隔受累的病例,强调了对非典型表现进行彻底评估和遗传评估的必要性。
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来源期刊
Diagnostic Pathology
Diagnostic Pathology 医学-病理学
CiteScore
4.60
自引率
0.00%
发文量
93
审稿时长
1 months
期刊介绍: Diagnostic Pathology is an open access, peer-reviewed, online journal that considers research in surgical and clinical pathology, immunology, and biology, with a special focus on cutting-edge approaches in diagnostic pathology and tissue-based therapy. The journal covers all aspects of surgical pathology, including classic diagnostic pathology, prognosis-related diagnosis (tumor stages, prognosis markers, such as MIB-percentage, hormone receptors, etc.), and therapy-related findings. The journal also focuses on the technological aspects of pathology, including molecular biology techniques, morphometry aspects (stereology, DNA analysis, syntactic structure analysis), communication aspects (telecommunication, virtual microscopy, virtual pathology institutions, etc.), and electronic education and quality assurance (for example interactive publication, on-line references with automated updating, etc.).
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