Next-Generation Nerve-Sparing Techniques in Robotic Radical Prostatectomy: A Contemporary Review.

Abstract

Purpose of review: To summarize the evolution and future of technologies and techniques that assist in providing good functional outcomes during nerve-sparing robot-assisted radical prostatectomy.

Recent findings: Recent data underscore the value of preoperative optimization, including structured weight loss and pharmacologic interventions such as GLP-1 receptor agonists, in facilitating safer and more precise nerve-sparing. Advances in imaging and surgical planning, including 3D modeling and augmented reality, have enhanced anatomic visualization and margin control. Intraoperative adjuncts such as frozen section analysis (NeuroSAFE), nerve mapping and fluorescence guidance are being evaluated to minimize neural injury. Next-generation robotic systems incorporating haptic feedback and intraoperative penile oxygen monitoring may provide real-time functional assessment. Early series suggest these technologies can improve early continence and potency recovery, though long-term validation is needed. The future of nerve-sparing prostatectomy lies in a precision-based, multimodal framework that integrates advanced imaging, intraoperative functional assessment, and patient-specific rehabilitation strategies. While robotic surgery has established a new benchmark for anatomic preservation hold promise for improving both oncologic and quality-of-life outcomes. Rigorous validation and standardized reporting will be critical to moving these innovations from investigational use into routine practice.