Pingping Su, Zhouhengte Xu, Liang Pang, Yirui Chen, Jiajia Dong, Yun Sun
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引用次数: 0
Abstract
Background: PCOS is a complex endocrine-metabolic disorder that is closely associated with oxidative stress. GEN, a naturally occurring isoflavone, has demonstrated beneficial effects in addressing hormonal imbalances and metabolic disturbances, primarily due to its potent antioxidant properties. While accumulating evidence supports its potential in managing PCOS, the full extent of GEN's therapeutic efficacy in alleviating PCOS-related symptoms remains inadequately defined, warranting further detailed investigation.
Purpose: This study aims to systematically evaluate the pharmacological efficacy of GEN in the management of PCOS through a meta-analytic synthesis of preclinical data.
Methods: A comprehensive literature search was conducted across six major databases-CNKI, Wanfang Data, VIP, PubMed, and Web of Science-covering publications from database inception until May 2025. The methodological quality of eligible studies was assessed using SYRCLE's risk of bias tool. Data synthesis and meta-analysis were performed using Rev Man 5.3 and Stata 17 software to ensure statistical analysis of the pooled outcomes.
Results: A total of ten studies were included in the meta-analysis. Compared to the control group, GEN exhibited significant therapeutic effects in the treatment of PCOS, including a reduction in body weight (P < 0.00001) and ovarian weight (P < 0.00001) in PCOS rats, as well as a reversal of elevated serum levels of T (P = 0.003) and LH (P < 0.00001). GEN also significantly reduced FBG (P = 0.007), INS (P = 0.0006), and HOMA-IR indices (P = 0.01), decreased MDA content (P = 0.0002) in ovarian tissue, and enhanced antioxidant activity, as indicated by increases in TAC (P < 0.00001), SOD (P < 0.00001), and GPx (P = 0.02). Furthermore, GEN lowered serum levels of LDL-C (P < 0.00001).
Conclusion: GEN demonstrates considerable therapeutic potential in managing PCOS through multiple mechanisms. These include modulation of body and ovarian weight, restoration of endocrine balance by reducing hyperandrogenism and normalizing reproductive hormone profiles, improvement of metabolic parameters through enhanced insulin sensitivity and glycemic control, and attenuation of oxidative stress via increased antioxidant enzyme activity and reduction of lipid peroxidation markers. These findings emphasize GEN's promise as a multifaceted intervention for PCOS, underscoring the need for further translational research to confirm its clinical efficacy.
背景:PCOS是一种复杂的内分泌代谢紊乱,与氧化应激密切相关。GEN是一种天然存在的异黄酮,主要由于其强大的抗氧化特性,已被证明对解决激素失衡和代谢紊乱有有益作用。虽然越来越多的证据支持其在治疗多囊卵巢综合征方面的潜力,但GEN在缓解多囊卵巢综合征相关症状方面的全部治疗效果仍未充分确定,需要进一步详细研究。目的:本研究旨在通过综合临床前数据的荟萃分析,系统评价GEN治疗PCOS的药理疗效。方法:对中国知网、万方数据、维普、PubMed和Web of science六大数据库进行全面的文献检索,涵盖从建库到2025年5月的出版物。使用sycle的偏倚风险工具评估合格研究的方法学质量。采用Rev Man 5.3和Stata 17软件进行数据综合和meta分析,确保合并结果的统计分析。结果:meta分析共纳入10项研究。与对照组相比,GEN对PCOS的治疗效果显著,包括减轻体重(P结论:GEN通过多种机制在治疗PCOS方面显示出相当大的治疗潜力。这些包括调节身体和卵巢重量,通过减少高雄激素和使生殖激素谱正常化来恢复内分泌平衡,通过增强胰岛素敏感性和血糖控制来改善代谢参数,以及通过增加抗氧化酶活性和减少脂质过氧化标记物来减轻氧化应激。这些发现强调了GEN作为多囊卵巢综合征的多方面干预的前景,强调了进一步的转化研究以确认其临床疗效的必要性。
期刊介绍:
BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.