Associations between ocular parameters and corneal astigmatism in young Chinese adults: a cross-sectional study.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

BMC Ophthalmology Pub Date : 2025-09-30 DOI:10.1186/s12886-025-04339-7

Fanglan Yuan, Hui Li, Jing Yang, Wangting Li, Keming Zhao, Lishi Luo, Xiaoxia Fang, Jiantao Wang, Wei Chi, Kun Zeng

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Abstract

Purpose: This study aims to explore the relationships between key ocular optical parameters and corneal astigmatism, providing new insights into the factors influencing astigmatic changes in the human eye.

Setting: The study was conducted at a tertiary eye care center with a population of adults.

Design: A cross-sectional, observational analysis of ocular measurements.

Methods: A total of 935 adults (507 males, 428 females; aged 21-44 years) participated. Inclusion criteria were adults with no history of ocular disease or surgery. Exclusion criteria included individuals with systemic diseases affecting ocular health. Ocular measurements including central corneal thickness (CCT), anterior chamber depth (ACD), axial length (AL), lens thickness (LT), vitreous thickness (VT), white-to-white diameter (WTW), spherical power (SPH), and cylindrical power (CYL) were obtained using the Suoer SW-9000 μm Plus biometer and Nidek ARK-1 Autorefractor. Corneal astigmatism (ΔK) was calculated as the difference between K2 and K1 within the 3 mm optical zone. Shapiro-Wilk, Pearson correlation, and stepwise multiple linear regression analyses were applied.

Results: ΔK was significantly correlated with age (r = -0.07, p = 0.030), AL (r = 0.10, p = 0.002), VT (r = 0.10, p = 0.002), SPH (r = -0.13, p < 0.001), and CYL (r = -0.77, p < 0.001). After multicollinearity diagnostics, VT was excluded (VIF > 10). Multiple linear regression identified AL (β = -0.269, 95% CI: -0.415 to -0.123, p = 0.002, VIF = 3.75), SPH (β = 0.072, 95% CI: 0.012 to 0.132, p = 0.018, VIF = 3.39), and cylindrical power (β = -0.806, 95% CI: -0.909 to -0.703, p < 0.001, VIF = 2.31) as significant predictors, with an adjusted R² of 0.608.

Conclusions: AL, SPH, and CYL significantly influence corneal astigmatism, suggesting corneal morphology is closely linked to ocular characteristics, which may aid in targeted approaches to diagnosis and management.

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中国年轻人眼部参数与角膜散光的关系：一项横断面研究。

目的：本研究旨在探讨眼部关键光学参数与角膜散光的关系，为人眼散光变化的影响因素提供新的认识。环境：本研究在一家三级眼科护理中心进行，研究对象为成年人。设计：眼部测量的横断面观察性分析。方法：共有935名成人参与，其中男性507人，女性428人，年龄21-44岁。纳入标准为无眼部疾病或手术史的成年人。排除标准包括患有影响眼部健康的全身性疾病的个体。使用Suoer SW-9000 μm Plus生物计和Nidek ARK-1自动折射镜测量角膜中央厚度（CCT）、前房深度（ACD）、轴向长度（AL）、晶状体厚度（LT）、玻璃体厚度（VT）、白到白直径（WTW）、球形度数（SPH）和圆柱形度数（CYL）。角膜散光（ΔK）计算为3 mm光学区的K2和K1之差。采用Shapiro-Wilk、Pearson相关和逐步多元线性回归分析。结果:ΔK与年龄显著相关(r = -0.07, p = 0.030),艾尔(r = 0.10, p = 0.002), VT (r = 0.10, p = 0.002), SPH (r = -0.13, p 10)。多元线性回归鉴定出AL （β = -0.269, 95% CI: -0.415至-0.123,p = 0.002, VIF = 3.75）、SPH （β = 0.072, 95% CI: 0.012至0.132,p = 0.018, VIF = 3.39）和圆柱形度数（β = -0.806, 95% CI: -0.909至-0.703,p）。结论：AL、SPH和CYL显著影响角膜散光，提示角膜形态与眼部特征密切相关，这可能有助于有针对性的诊断和治疗。

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来源期刊

BMC Ophthalmology OPHTHALMOLOGY-

CiteScore

3.40

自引率

5.00%

发文量

441

审稿时长

6-12 weeks

期刊介绍： BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.