Treatment-resistant depression with poor response to deep brain stimulation improves with psychotherapy: case series.

IF 3.6 3区医学 Q1 PSYCHIATRY

Annals of General Psychiatry Pub Date : 2025-09-30 DOI:10.1186/s12991-025-00588-4

Shuping Fang, Yingyi Kang, Jun Zhang

{"title":"Treatment-resistant depression with poor response to deep brain stimulation improves with psychotherapy: case series.","authors":"Shuping Fang, Yingyi Kang, Jun Zhang","doi":"10.1186/s12991-025-00588-4","DOIUrl":null,"url":null,"abstract":"Background: Deep brain stimulation (DBS) is regarded as an efficacious treatment for treatment-resistant depression (TRD), exhibiting a response rate of approximately 60%. However, certain patients exhibit limited responsiveness to DBS, necessitating further exploration of alternative interventions. In this paper, we present two cases of TRD patients who exhibited poor response to DBS surgery but showed significant improvement after receiving psychotherapy.Case presentation: In case 1, a 20-year-old female patient exhibited a slight initial positive response after DBS surgery; however, her symptoms continued to deteriorate progressively. Following systematic cognitive behavioral therapy (CBT), she demonstrated remarkable improvement in depressive symptoms. In case 2, a 36-year-old male patient experienced short-term symptomatic improvement post-DBS surgery but relapsed due to treatment interruption caused by financial constraints. After CBT intervention, the symptoms of his depression exhibited significant improvement.Conclusions: No previous studies have reported on the effects of CBT in postoperative depressive symptoms following DBS. The combination of DBS surgery and postoperative psychological therapy may enhance the therapeutic outcomes of DBS. This study emphasizes the significance of incorporating psychotherapy into the management after DBS surgery and calls for future research to further investigate the potential and mechanisms underlying this comprehensive treatment strategy.","PeriodicalId":7942,"journal":{"name":"Annals of General Psychiatry","volume":"24 1","pages":"57"},"PeriodicalIF":3.6000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482072/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of General Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12991-025-00588-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Deep brain stimulation (DBS) is regarded as an efficacious treatment for treatment-resistant depression (TRD), exhibiting a response rate of approximately 60%. However, certain patients exhibit limited responsiveness to DBS, necessitating further exploration of alternative interventions. In this paper, we present two cases of TRD patients who exhibited poor response to DBS surgery but showed significant improvement after receiving psychotherapy.

Case presentation: In case 1, a 20-year-old female patient exhibited a slight initial positive response after DBS surgery; however, her symptoms continued to deteriorate progressively. Following systematic cognitive behavioral therapy (CBT), she demonstrated remarkable improvement in depressive symptoms. In case 2, a 36-year-old male patient experienced short-term symptomatic improvement post-DBS surgery but relapsed due to treatment interruption caused by financial constraints. After CBT intervention, the symptoms of his depression exhibited significant improvement.

Conclusions: No previous studies have reported on the effects of CBT in postoperative depressive symptoms following DBS. The combination of DBS surgery and postoperative psychological therapy may enhance the therapeutic outcomes of DBS. This study emphasizes the significance of incorporating psychotherapy into the management after DBS surgery and calls for future research to further investigate the potential and mechanisms underlying this comprehensive treatment strategy.

查看原文本刊更多论文

对深部脑刺激反应不佳的难治性抑郁症通过心理治疗得到改善：病例系列。

背景：脑深部电刺激（DBS）被认为是治疗难治性抑郁症（TRD）的有效方法，其有效率约为60%。然而，某些患者对DBS的反应有限，需要进一步探索替代干预措施。在本文中，我们报告了两例TRD患者，他们对DBS手术反应不佳，但在接受心理治疗后有明显改善。病例介绍：病例1，一名20岁的女性患者在DBS手术后表现出轻微的初始阳性反应；然而，她的症状继续逐渐恶化。经过系统的认知行为治疗（CBT），她的抑郁症状得到了显著改善。病例2为36岁男性患者，dbs手术后症状短期改善，但因经济拮据中断治疗复发。经CBT干预后，其抑郁症状有明显改善。结论：以前没有研究报道CBT对DBS术后抑郁症状的影响。DBS手术与术后心理治疗相结合可提高DBS的治疗效果。本研究强调了将心理治疗纳入DBS手术后管理的重要性，并呼吁未来的研究进一步探讨这种综合治疗策略的潜力和机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of General Psychiatry PSYCHIATRY-

CiteScore

6.60

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.