Evaluation of Antimicrobial Activity of Aloe vera Gel Extract on Hospital-Acquired Methicillin-Resistant Staphylococcus aureus.

IF 2.3 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

BioMed Research International Pub Date : 2025-09-21 eCollection Date: 2025-01-01 DOI:10.1155/bmri/8787650

Jones Gyamerah, Justice Kumi, Eric N Y Nyarko, Janet Ampofo, Sherif Hamidu, Eunice E Ampem-Danso, Vida Yirenkyiwaa Adjei, Felicia Owusu

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引用次数: 0

Abstract

Introduction: Aloe vera has a long history as a medicinal plant with numerous therapeutic uses. Methicillin-resistant Staphylococcus aureus (MRSA) is a type of bacteria resistant to commonly used antibiotics such as penicillin. Hospital-acquired methicillin-resistant Staphylococcus aureus (Ha-MRSA) refers to MRSA infections that arise in healthcare settings, usually 48 h or longer after hospital admission or in individuals with recent hospitalization. This research is aimed at investigating the effectiveness of Aloe vera gel extract against Ha-MRSA. Methods: The agar well boring diffusion and the broth dilution test methods were employed, respectively, to assess the susceptibility of Ha-MRSA to Aloe vera gel extract in ethanol and DMSO medium. These extraction media were compared for their effectiveness as the solvent of extraction for the susceptibility test. Results: A minimum inhibitory concentration of 0.2 mg/L of Aloe vera gel extract in the ethanolic extraction medium was achieved, indicating susceptibility of the Ha-MRSA strain as recommended by EUCAST/ESCMID. Conclusion: Aloe vera gel ethanol extract was sensitive against Ha-MRSA strains but was resistant in the DMSO extraction method. It is recommended that further research be carried out to ascertain the bioactive compounds responsible for antimicrobial activity.

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芦荟凝胶提取物对医院获得性耐甲氧西林金黄色葡萄球菌的抑菌活性评价。

芦荟作为一种药用植物有着悠久的历史，具有许多治疗用途。耐甲氧西林金黄色葡萄球菌（MRSA）是一种对常用抗生素如青霉素耐药的细菌。医院获得性耐甲氧西林金黄色葡萄球菌（Ha-MRSA）是指在医疗机构中发生的MRSA感染，通常发生在入院后48小时或更长时间，或发生在最近住院的个体中。本研究旨在探讨芦荟凝胶提取物对Ha-MRSA的有效性。方法：分别采用琼脂孔扩散法和肉汤稀释法测定Ha-MRSA对芦荟凝胶提取物在乙醇和DMSO培养基中的敏感性。比较了这些提取介质作为提取溶剂的敏感性试验。结果：芦荟凝胶提取物在乙醇提取培养基中的最低抑菌浓度为0.2 mg/L，表明Ha-MRSA菌株具有EUCAST/ESCMID推荐的敏感性。结论：芦荟凝胶乙醇提取物对Ha-MRSA敏感，DMSO提取法对Ha-MRSA耐药。建议进行进一步的研究以确定具有抗菌活性的生物活性化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

6.70

自引率

0.00%

发文量

1942

审稿时长

19 weeks

期刊介绍： BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.