Ultra-convenient and rapid synthesis of FeAg MOGs for sensitive test strips detection of dopamine in human serum

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-09-30 DOI:10.1007/s00604-025-07565-4

Kangyi Guo, Yipi Xiao, Yun He, Jie Liu, Liang Guo, Aiping Fan, Zheling Zeng, Xiangjuan Zheng, Xiluan Yan

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Abstract

Metal-organic gels (MOGs) represent the unique category of metal-organic materials, notably distinguished by their expansive specific surface area, highly porous structural frameworks, and readily accessible metallic active sites. This investigation involved the synthesis of FeAg MOGs at ambient temperature using 1,3,5-phenyltricarboxylic acid (H₃BTC) as a ligand through a simple, one-step method. The resultant FeAg MOGs exhibit excellent oxidase activity, capable of oxidizing 3,3',5,5'-tetramethylbenzidine (TMB) into blue oxTMB. In experimental studies we have discovered that dopamine (DA) exhibits the specific inhibitory effect on the colorimetric response of the FeAg MOGs-TMB system. Based on this a simple, rapid, and sensitive colorimetric method for the selective detection of DA was developed. This methodology possesses a ultra-wide detection range (linear range: 2 μM to 5000 μM) with a detection limit (LOD, S/N = 3) of 1.324 μM. It has proven effective and has been utilized successfully for the quantitative testing of DA in samples of human serum. Furthermore, a test paper has been designed to visually determine DA concentration within a range 2 μM to 1000 μM. The study demonstrates the enormous potential of MOGs for application in the field of colorimetric analysis.

Graphical Abstract

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超方便快速合成用于人血清多巴胺敏感试纸的FeAg MOGs。

金属有机凝胶（mog）是一类独特的金属有机材料，其显著特点是具有广阔的比表面积、高度多孔的结构框架和易于接近的金属活性位点。本研究以1,3,5-苯基三羧酸（H3BTC）为配体，通过简单的一步法在常温下合成FeAg MOGs。得到的FeAg MOGs表现出优异的氧化酶活性，能够将3,3',5,5'-四甲基联苯胺（TMB）氧化为蓝色的oxTMB。在实验研究中，我们发现多巴胺（DA）对FeAg MOGs-TMB系统的比色反应具有特异性抑制作用。在此基础上，建立了一种简单、快速、灵敏的选择性检测DA的比色法。该方法具有超宽的检测范围（线性范围为2 μM ~ 5000 μM），检测限（LOD, S/N = 3）为1.324 μM。它已被证明是有效的，并已成功地用于人血清样品中DA的定量检测。此外，还设计了一种测试纸，可以直观地测定2 μM ~ 1000 μM范围内的DA浓度。该研究证明了mog在比色分析领域的巨大应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.