{"title":"Recent Advances on Dehydroalanine-Specific Modification and Diversification of Peptides and Proteins.","authors":"Changjun Yu, Guangjun Bao, Wangsheng Sun","doi":"10.1002/cbic.202500349","DOIUrl":null,"url":null,"abstract":"<p><p>In recent years, chemical modification techniques based on dehydroalanine (Dha) have become a prominent area in the functionalization of peptides and proteins due to their high efficiency and site selectivity. This article reviews the recent advancements in the modification of Dha-containing peptides and proteins. Focusing on the chemical properties of Dha, the advantages of nucleophilic addition reactions, free radical chemistry, metal-catalyzed cross-coupling reactions, and cycloaddition reactions in peptide and protein modification are discussed, as well as their applicability in the development of novel biocompatible methods. Additionally, the article explores the current limitations of these techniques and highlights future challenges that need to be addressed.</p>","PeriodicalId":140,"journal":{"name":"ChemBioChem","volume":" ","pages":"e202500349"},"PeriodicalIF":2.8000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemBioChem","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1002/cbic.202500349","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In recent years, chemical modification techniques based on dehydroalanine (Dha) have become a prominent area in the functionalization of peptides and proteins due to their high efficiency and site selectivity. This article reviews the recent advancements in the modification of Dha-containing peptides and proteins. Focusing on the chemical properties of Dha, the advantages of nucleophilic addition reactions, free radical chemistry, metal-catalyzed cross-coupling reactions, and cycloaddition reactions in peptide and protein modification are discussed, as well as their applicability in the development of novel biocompatible methods. Additionally, the article explores the current limitations of these techniques and highlights future challenges that need to be addressed.
期刊介绍：
ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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