Progress of Micro/Nanomotors for In Vivo Biomedical Applications.

IF 9.6 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Yang Su, Huixue Feng, Xue Yuan, Qijing Du, Hongning Jiang, Rongwei Han, Yongxin Yang, Changyong Gao, Rongbo Fan
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引用次数: 0

Abstract

As a new-generation intelligent diagnostic and therapeutic platform, micro/nanomotors (MNMs) hold great promise for overcoming the limitations of conventional passive drug delivery systems, such as poor penetration across physiological barriers. By converting chemical, optical, acoustic, or magnetic energy into kinetic motion, MNMs enable actively propelled, targeted delivery, making them a promising emerging tool for precision medicine. This review provides a comprehensive overview of the progress in the propulsion mechanisms and motion control strategies of MNMs, emphasizing how to achieve controllable movement in vivo. The in vivo biological applications of MNMs are highlighted, including penetration of the blood-retinal barrier for ophthalmic therapies, crossing of the blood-brain barrier (BBB) for neurological interventions, targeted drug release to chronic inflammatory sites, intelligent gastrointestinal drug administration, precision thrombosis in cardiovascular diseases, and the advancement of multimodal cancer therapies. The key challenges and outlooks of MNMs for clinical translation are discussed.

微/纳米马达在体内生物医学应用的研究进展。
作为新一代的智能诊断和治疗平台,微/纳米运动(MNMs)有望克服传统被动给药系统的局限性,如穿透生理屏障的能力差。通过将化学,光学,声学或磁能转化为动能,MNMs能够主动推进,有针对性的递送,使其成为精准医疗的有前途的新兴工具。本文综述了纳米机器人的推进机制和运动控制策略的研究进展,重点介绍了如何在体内实现可控运动。纳米颗粒在体内的生物学应用,包括穿透血视网膜屏障用于眼科治疗,穿过血脑屏障(BBB)用于神经干预,靶向药物释放到慢性炎症部位,智能胃肠道给药,心血管疾病的精确血栓形成,以及多模式癌症治疗的进展。讨论了临床翻译中MNMs的主要挑战和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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