Demographic and Clinical Characteristics of Lithium-Treated Older Adults With Bipolar Disorder: A Replication Study From the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project

IF 5 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2025-07-10 DOI:10.1111/acps.70016

Orestes V. Forlenza, Ni Xu, Peijun Chen, Soham Rej, Ariel G. Gildengers, Tomas Hajek, Martha Sajatovic, the GAGE-BD initiative

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引用次数: 0

Abstract

Objectives

To replicate a previous study addressing differences and similarities of older adults with bipolar disorder (OABD) treated with lithium as compared to those treated with other drugs.

Methods

Cross-sectional analysis of a harmonized dataset of the GAGE-BD Project, with over 2 thousand participants enrolled from two recruitment waves, with worldwide representation. Participants were allocated in two treatment groups according to the availability of information about current lithium use (Lithium, n = 754; Non-lithium, n = 1,161). We used linear regression, linear mixed and generalized linear mixed models to examine the associations between treatment groups and other variables, with emphasis on the distribution of socio-demographical and clinical variables, controlling for age, gender, and study site.

Results

We found statistical associations between lithium use and higher education level, as well as with bipolar-1 subtype, and a negative association with comorbid anxiety disorder. OABD patients treated with lithium had lower scores on depression rating scales, and better overall global cognitive and functional state. Lithium users also reported having fewer cardiovascular comorbidities.

Conclusion

We found several potentially relevant differences in the clinical profile of OABD treated with lithium; nonetheless, the interpretation of the present results must take into account the methodological limitations inherent to the cross-sectional approach and data harmonization.

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锂治疗老年双相情感障碍的人口学和临床特征：一项来自全球老年双相情感障碍实验（GAGE-BD）项目的复制研究

目的重复先前的一项研究，研究锂治疗老年双相情感障碍（OABD）与其他药物治疗的差异和相似之处。方法对GAGE-BD项目的统一数据集进行横断面分析，该数据集从两波招募中招募了2000多名参与者，具有全球代表性。根据当前锂使用信息的可用性，参与者被分配到两个治疗组（锂，n = 754；非锂，n = 1161）。我们使用线性回归、线性混合和广义线性混合模型来检验治疗组与其他变量之间的关联，重点关注社会人口统计学和临床变量的分布，控制年龄、性别和研究地点。结果我们发现锂的使用与高等教育水平以及双相1亚型之间存在统计学相关性，与共病性焦虑症呈负相关。接受锂治疗的OABD患者在抑郁评定量表上得分较低，整体认知和功能状态较好。锂盐使用者报告的心血管合并症也较少。结论我们发现锂治疗OABD的临床特征存在一些潜在的相关差异；然而，对目前结果的解释必须考虑到横断面方法和数据协调所固有的方法局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.