Hydroxyapatite-based nanocomposite scaffolds for bone regeneration

IF 2.3 4区材料科学 Q2 MATERIALS SCIENCE, CERAMICS

International Journal of Applied Ceramic Technology Pub Date : 2025-08-05 DOI:10.1111/ijac.70041

Ashkan Farazin, Seyedeh Farnaz Darghiasi

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Abstract

Hydroxyapatite (HAp), a naturally occurring calcium phosphate, remains one of the most promising bioceramics for orthopedic and dental applications due to its excellent biocompatibility, osteoconductivity, and structural similarity to natural bone mineral. While previous studies have explored HAp's basic properties, this review offers a comprehensive and integrated analysis of its synthesis methods, physicochemical properties, and biological performance, alongside critical comparisons and future-oriented insights. A key novelty of this review is the incorporation of a 3PM analysis evaluating prior art, publications, products, and megatrends to assess translational readiness and strategic value. Furthermore, the review uniquely highlights biowaste-derived HAp, sustainability implications in alignment with United Nations Sustainable Development Goals, and the underrepresented role of analytical and simulation models in HAp optimization. By connecting material science with ecological balance, cost-effectiveness, and long-term clinical potential, this review serves as a strategic roadmap for the next generation of HAp-based biomaterials in regenerative medicine.

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羟基磷灰石基纳米复合材料骨再生支架

羟基磷灰石（HAp）是一种天然存在的磷酸钙，由于其优异的生物相容性、骨导电性和与天然骨矿物结构相似，仍然是骨科和牙科应用中最有前途的生物陶瓷之一。虽然以前的研究已经探索了HAp的基本性质，但本综述对其合成方法，物理化学性质和生物性能进行了全面综合的分析，并进行了关键的比较和面向未来的见解。本综述的一个关键新颖之处在于结合了3PM分析，评估现有技术、出版物、产品和大趋势，以评估转化准备和战略价值。此外，该综述独特地强调了生物废物衍生的HAp，与联合国可持续发展目标一致的可持续性影响，以及分析和模拟模型在HAp优化中的代表性不足的作用。通过将材料科学与生态平衡、成本效益和长期临床潜力联系起来，本综述为再生医学中下一代基于hap的生物材料提供了战略路线图。

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来源期刊

International Journal of Applied Ceramic Technology 工程技术-材料科学：硅酸盐

CiteScore

3.90

自引率

9.50%

发文量

280

审稿时长

4.5 months

期刊介绍： The International Journal of Applied Ceramic Technology publishes cutting edge applied research and development work focused on commercialization of engineered ceramics, products and processes. The publication also explores the barriers to commercialization, design and testing, environmental health issues, international standardization activities, databases, and cost models. Designed to get high quality information to end-users quickly, the peer process is led by an editorial board of experts from industry, government, and universities. Each issue focuses on a high-interest, high-impact topic plus includes a range of papers detailing applications of ceramics. Papers on all aspects of applied ceramics are welcome including those in the following areas: Nanotechnology applications; Ceramic Armor; Ceramic and Technology for Energy Applications (e.g., Fuel Cells, Batteries, Solar, Thermoelectric, and HT Superconductors); Ceramic Matrix Composites; Functional Materials; Thermal and Environmental Barrier Coatings; Bioceramic Applications; Green Manufacturing; Ceramic Processing; Glass Technology; Fiber optics; Ceramics in Environmental Applications; Ceramics in Electronic, Photonic and Magnetic Applications;