Vertical Transmission of Gut Dysbiosis From Mothers With Gestational Diabetes to Infants

IF 3.7 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Jia Ming Low, Abhishek Gupta, Rachel Toh, Su Lin Lim, Shiao-Yng Chan, Sanjay Swarup, Le Ye Lee
{"title":"Vertical Transmission of Gut Dysbiosis From Mothers With Gestational Diabetes to Infants","authors":"Jia Ming Low,&nbsp;Abhishek Gupta,&nbsp;Rachel Toh,&nbsp;Su Lin Lim,&nbsp;Shiao-Yng Chan,&nbsp;Sanjay Swarup,&nbsp;Le Ye Lee","doi":"10.1111/1753-0407.70148","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Vertical transmission of microbes from a mother's gut to their offspring plays a crucial role in the genesis of the early life gut microbiome. Gestational Diabetes Mellitus (GDM) is the commonest metabolic disorder during pregnancy, which has adverse short- and long-term effects on both maternal and infant health. We aimed to capture the GDM-associated biosignatures in infants' gut microbiome from birth to the first 6 weeks of life.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>53 GDM mother-infant dyads and 16 healthy mother-infant dyads were recruited. We performed targeted 16S rRNA gene amplicon sequencing on stool samples. Various statistical analyses were performed to understand the changes in the microbiome profile of infants and identify GDM-associated bacterial biomarkers in mothers and their transfer to infants.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>GDM altered the gut microbiome of pregnant women as compared to healthy counterparts (PERMANOVA, <i>p</i>.adjusted &lt; 0.05), with predominance of bacterial members associated with insulin resistance, proinflammatory conditions, and other metabolic processes. Infants born to GDM mothers have distinctive early life microbiome (meconium and six weeks stools) compared to infants born to control mothers (PERMANOVA, <i>p</i>.adjusted &lt; 0.05). We also identified the presence of various GDM-associated microbial signatures such as <i>Blautia</i> and <i>Collinsella</i> in both meconium and one-month-old stool samples of infants born to GDM mothers.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This study provides a better understanding of the impact of GDM on the seeding of a specific set of microbes during the early life colonization event in the infant gut that increases the risk of inflammatory and metabolic diseases in the future.</p>\n </section>\n </div>","PeriodicalId":189,"journal":{"name":"Journal of Diabetes","volume":"17 10","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/1753-0407.70148","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/1753-0407.70148","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Vertical transmission of microbes from a mother's gut to their offspring plays a crucial role in the genesis of the early life gut microbiome. Gestational Diabetes Mellitus (GDM) is the commonest metabolic disorder during pregnancy, which has adverse short- and long-term effects on both maternal and infant health. We aimed to capture the GDM-associated biosignatures in infants' gut microbiome from birth to the first 6 weeks of life.

Methods

53 GDM mother-infant dyads and 16 healthy mother-infant dyads were recruited. We performed targeted 16S rRNA gene amplicon sequencing on stool samples. Various statistical analyses were performed to understand the changes in the microbiome profile of infants and identify GDM-associated bacterial biomarkers in mothers and their transfer to infants.

Results

GDM altered the gut microbiome of pregnant women as compared to healthy counterparts (PERMANOVA, p.adjusted < 0.05), with predominance of bacterial members associated with insulin resistance, proinflammatory conditions, and other metabolic processes. Infants born to GDM mothers have distinctive early life microbiome (meconium and six weeks stools) compared to infants born to control mothers (PERMANOVA, p.adjusted < 0.05). We also identified the presence of various GDM-associated microbial signatures such as Blautia and Collinsella in both meconium and one-month-old stool samples of infants born to GDM mothers.

Conclusion

This study provides a better understanding of the impact of GDM on the seeding of a specific set of microbes during the early life colonization event in the infant gut that increases the risk of inflammatory and metabolic diseases in the future.

Abstract Image

妊娠期糖尿病母亲对婴儿肠道生态失调的垂直传播
微生物从母体肠道垂直传播到其后代在早期生命肠道微生物群的形成中起着至关重要的作用。妊娠期糖尿病(GDM)是妊娠期最常见的代谢紊乱,对母婴健康有短期和长期的不良影响。我们的目标是捕捉婴儿从出生到出生后6周肠道微生物组中与gdm相关的生物特征。方法招募53例GDM母婴对和16例健康母婴对。我们对粪便样本进行了靶向16S rRNA基因扩增子测序。研究人员进行了各种统计分析,以了解婴儿微生物组谱的变化,并确定母亲体内与gdm相关的细菌生物标志物及其向婴儿的转移。结果与健康孕妇相比,GDM改变了孕妇的肠道微生物群(PERMANOVA, p校正<; 0.05),与胰岛素抵抗、促炎条件和其他代谢过程相关的细菌成员占主导地位。与对照组母亲所生的婴儿相比,GDM母亲所生的婴儿具有独特的早期生命微生物群(胎便和六周便)(PERMANOVA, p.校正<; 0.05)。我们还在GDM母亲所生婴儿的胎便和一个月大的粪便样本中发现了各种与GDM相关的微生物特征,如Blautia和Collinsella。结论本研究更好地了解了GDM对婴儿肠道早期定殖事件中特定微生物播种的影响,从而增加了未来炎症和代谢疾病的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Diabetes
Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
2.20%
发文量
94
审稿时长
>12 weeks
期刊介绍: Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信