Iridium‐Catalyzed α‐C–H Alkenylation of Alkylamines with Alkynes Followed by Alkene Isomerization Into Enamines

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-09-29 DOI:10.1002/adsc.70055

Yuki Takahashi , Kentaro Yamakawa , Takahiro Nishimura

引用次数: 0

Abstract

The iridium‐catalyzed intermolecular α‐C–H alkenylation of N‐methyl‐2‐aminopyridine derivatives proceeds via alkene isomerization to give the corresponding enamines. The reaction is efficiently catalyzed by a cationic iridium catalyst under mild reaction conditions. The same catalytic system can also be applied to the intramolecular C–H addition to alkynes to give cyclic ketones after hydrolysis of the corresponding enamines.

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铱催化α - C-H烷基胺与炔烃的烯基化，随后烯烃异构化成烯胺

铱催化的N -甲基- 2 -氨基吡啶衍生物的分子间α - C-H烯基化通过烯异构化得到相应的胺。在温和的反应条件下，阳离子铱催化剂能有效催化该反应。同样的催化体系也可以应用于相应的胺类水解后，在分子内碳氢加成成环酮。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.