Recent Advances in Metal–Organic Framework-Based Luminescent Sensors toward 3-Nitrotyrosine Biomarker

IF 3.4 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Crystal Growth & Design Pub Date : 2025-09-18 DOI:10.1021/acs.cgd.5c01152

Xiaoting Li, , , Huanrong Hao, , , Liying Liu, , , Hu Ren, , , Jingrui Yin, , , Junmu Wang, , , Lu Zhang, , , Xiutang Zhang*, , and , Liming Fan*,

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Abstract

3-Nitrotyrosine (3-NT), as a specific biomarker of protein oxidative stress damage, is of great significance in the early diagnosis of various diseases. This review systematically summarizes the latest research progress and specific applications of metal–organic framework (MOF)-based luminescent sensors for detecting 3-NT in aqueous media and biological samples. It focuses on the classification and detection capacity of MOF-based 3-NT luminescent sensors. Besides, the main sensing mechanisms, including structural collapse (SC), photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), competition absorption (CA), internal filtration effect (IFE), and dynamic quenching effect (DQE), are analyzed in depth. This review critically assesses current research progress, challenges, and future directions of MOF-based 3-NT detection, offering valuable insights for developing highly sensitive and selective MOF-based luminescent sensors. These insights will be instrumental in steering the field toward innovative and practical solutions, facilitating the design of sensors with enhanced performance and broader applicability.

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基于金属-有机框架的3-硝基酪氨酸生物标志物发光传感器研究进展

3-硝基酪氨酸（3-NT）作为蛋白质氧化应激损伤的特异性生物标志物，在多种疾病的早期诊断中具有重要意义。本文系统综述了基于金属有机框架（MOF）的发光传感器在水介质和生物样品中3-NT检测中的最新研究进展和具体应用。重点研究了基于mof的3-NT发光传感器的分类和检测能力。此外，还对结构坍缩（SC）、光致电子转移（PET）、荧光共振能量转移（FRET）、竞争吸收（CA）、内部过滤效应（IFE）和动态猝灭效应（DQE）等主要传感机制进行了深入分析。本文综述了目前基于mof的3-NT检测的研究进展、挑战和未来方向，为开发高灵敏度和选择性的mof发光传感器提供了有价值的见解。这些见解将有助于引导该领域走向创新和实用的解决方案，促进具有增强性能和更广泛适用性的传感器的设计。

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来源期刊

Crystal Growth & Design 化学-材料科学：综合

CiteScore

6.30

自引率

10.50%

发文量

650

审稿时长

1.9 months

期刊介绍： The aim of Crystal Growth & Design is to stimulate crossfertilization of knowledge among scientists and engineers working in the fields of crystal growth, crystal engineering, and the industrial application of crystalline materials. Crystal Growth & Design publishes theoretical and experimental studies of the physical, chemical, and biological phenomena and processes related to the design, growth, and application of crystalline materials. Synergistic approaches originating from different disciplines and technologies and integrating the fields of crystal growth, crystal engineering, intermolecular interactions, and industrial application are encouraged.