Research Progress on Regulating Autophagy in Traditional Chinese Medicine for the Treatment of Traumatic Brain Injury

IF 4.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-09-18 DOI:10.1021/acsomega.5c06298

Yan Cao, , , Hengxi Li, , , Hongyan Jiang, , , Xinyuan Luo, , , Aiping Yin, , , Jia Wu, , , Xiaobing Guo*, , , Haiying Wu*, , and , Ping Li*,

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Abstract

Traumatic brain injury (TBI), characterized by structural brain damage caused by external physical shocks, is a significant global health challenge. Autophagy plays an important role in the cellular self-protection mechanism during its pathological progression. Traditional Chinese medicine (TCM) has a long history and unique advantages in neuroprotection. This review summarizes the key markers of autophagy and the relevant signaling pathways involved in autophagy in TBI, mainly including the PI3K/Akt/mTOR, AMPK/mTOR, Nrf2, TLR4 signaling pathways, and the endoplasmic reticulum stress autophagy axis. In addition, this paper summarizes the recent advances in TCM approaches in TBI autophagy treatment, such as terpenoids, flavonoids, polyphenols, alkaloids, and carotenoids, which are active components of TCM, as well as acupuncture nonpharmacological therapies.

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中药调节自噬治疗创伤性脑损伤的研究进展

外伤性脑损伤（TBI）是一项重大的全球健康挑战，其特征是外部物理冲击造成的结构性脑损伤。自噬在其病理发展过程中，在细胞自我保护机制中起着重要作用。中医在神经保护方面有着悠久的历史和独特的优势。本文综述了脑外伤自噬的关键标志物及参与自噬的相关信号通路，主要包括PI3K/Akt/mTOR、AMPK/mTOR、Nrf2、TLR4信号通路以及内质网应激自噬轴。此外，本文还综述了近年来中药治疗TBI自噬的研究进展，包括中药有效成分萜类、黄酮类、多酚类、生物碱类、类胡萝卜素类以及针刺非药物治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.