{"title":"Visual interpretation of [18F]Florzolotau Tau-PET imaging for differentiating alzheimer's disease and progressive supranuclear palsy.","authors":"Huan-Chun Lin,Kuo-Lun Huang,Shih-Hsin Chen,Tsung-Ying Ho,Chin-Chang Huang,Jung-Lung Hsu,Chiung-Chih Chang,Kun-Ju Lin,Ing-Tsung Hsiao","doi":"10.1007/s00259-025-07539-x","DOIUrl":null,"url":null,"abstract":"INTRODUCTION\r\nTau accumulation in the brain is a hallmark of both Alzheimer's disease (AD) and progressive supranuclear palsy (PSP), complicating differential diagnosis. The novel [18F]Florzolotau tauPET enables invivo detection. This study tests a visual reading approach on [18F]Florzolotau PET for reliably separating AD from PSP and assessing its clinical usefulness.\r\n\r\nMETHODS\r\nEightynine participants of Aβpositive AD, Aβnegative PSP, and cognitively unimpaired controls (CU) underwent [18F]Florzolotau PET, [18F]Florbetapir amyloidPET, and MRI. Visual interpretation of the tau-PET scans was performed using a colormap-based method, dividing the brain into AD-specific regions and PSP-specific regions. Regional tau uptake was scored visually, and the results were compared with SUVr values from quantitative analysis. Decision tree analysis was used to classify patients based on visual scores.\r\n\r\nRESULTS\r\nThe study found significant differences in visual scores between the CU, AD, and PSP groups, particularly in the AD-specific and PSP-specific regions. Visual assessment of tau uptake moderately correlated with SUVr values, especially in AD-specific regions. The decision tree model using visual scores accurately classified CU, AD, and PSP patients, with sensitivity and specificity rates exceeding 85%. Interobserver agreement for visual scoring was high, supporting the reliability of this method in clinical settings.\r\n\r\nCONCLUSION\r\nVisual interpretation scoring system of [18F] Florzolotau tau-PET reliably distinguishes AD from PSP, shows strong correlations with diagnoses, and is simpler than quantitative analyses for routine practice. Larger cohorts must confirm accuracy, refine the method, and assess its ability to grade disease severity.","PeriodicalId":11909,"journal":{"name":"European Journal of Nuclear Medicine and Molecular Imaging","volume":"157 1","pages":""},"PeriodicalIF":7.6000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Nuclear Medicine and Molecular Imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00259-025-07539-x","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
INTRODUCTION
Tau accumulation in the brain is a hallmark of both Alzheimer's disease (AD) and progressive supranuclear palsy (PSP), complicating differential diagnosis. The novel [18F]Florzolotau tauPET enables invivo detection. This study tests a visual reading approach on [18F]Florzolotau PET for reliably separating AD from PSP and assessing its clinical usefulness.
METHODS
Eightynine participants of Aβpositive AD, Aβnegative PSP, and cognitively unimpaired controls (CU) underwent [18F]Florzolotau PET, [18F]Florbetapir amyloidPET, and MRI. Visual interpretation of the tau-PET scans was performed using a colormap-based method, dividing the brain into AD-specific regions and PSP-specific regions. Regional tau uptake was scored visually, and the results were compared with SUVr values from quantitative analysis. Decision tree analysis was used to classify patients based on visual scores.
RESULTS
The study found significant differences in visual scores between the CU, AD, and PSP groups, particularly in the AD-specific and PSP-specific regions. Visual assessment of tau uptake moderately correlated with SUVr values, especially in AD-specific regions. The decision tree model using visual scores accurately classified CU, AD, and PSP patients, with sensitivity and specificity rates exceeding 85%. Interobserver agreement for visual scoring was high, supporting the reliability of this method in clinical settings.
CONCLUSION
Visual interpretation scoring system of [18F] Florzolotau tau-PET reliably distinguishes AD from PSP, shows strong correlations with diagnoses, and is simpler than quantitative analyses for routine practice. Larger cohorts must confirm accuracy, refine the method, and assess its ability to grade disease severity.
期刊介绍:
The European Journal of Nuclear Medicine and Molecular Imaging serves as a platform for the exchange of clinical and scientific information within nuclear medicine and related professions. It welcomes international submissions from professionals involved in the functional, metabolic, and molecular investigation of diseases. The journal's coverage spans physics, dosimetry, radiation biology, radiochemistry, and pharmacy, providing high-quality peer review by experts in the field. Known for highly cited and downloaded articles, it ensures global visibility for research work and is part of the EJNMMI journal family.