Enhanced Wound Healing Using Curcumin-Loaded Janus Dressings Fabricated by Femtosecond Laser-Assisted Molding.

IF 8.2 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2025-10-01 DOI:10.1021/acsami.5c13577

Jie Yang,Shuxuan Zhao,Lan Jiang,Jie Hu,Xushi Niu,Junjun Ni,Weina Han

{"title":"Enhanced Wound Healing Using Curcumin-Loaded Janus Dressings Fabricated by Femtosecond Laser-Assisted Molding.","authors":"Jie Yang,Shuxuan Zhao,Lan Jiang,Jie Hu,Xushi Niu,Junjun Ni,Weina Han","doi":"10.1021/acsami.5c13577","DOIUrl":null,"url":null,"abstract":"Wound dressings play crucial roles in clinical wound management, serving as integral components repairing of damaged skin barriers. Herein, a curcumin-loaded asymmetric-wettability Janus polydimethylsiloxane wound dressing with surface microstructures is developed via a combined approach involving femtosecond laser technology and template replication. The prepared dressing has a hydrophobic outer surface, which offers antifouling and anticontamination characteristics, and an inner surface featuring groove-like micro/nanostructures with a hydrophilic coating, which collectively improve in vitro NIH/3T3 cell proliferation. Furthermore, the structures significantly increase the loading efficiency of curcumin and decrease its release rate, improving the antibacterial properties of the dressing. In vivo evaluation showed that the dressing effectively accelerates wound healing and epithelial tissue regeneration, achieving a wound healing rate of 95.89% within after 13 days of treatment. This study provides valuable insights into the design and development of drug-loaded Janus wound dressings, which have promising potential for improving wound healing outcomes.","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"11 1","pages":""},"PeriodicalIF":8.2000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acsami.5c13577","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Wound dressings play crucial roles in clinical wound management, serving as integral components repairing of damaged skin barriers. Herein, a curcumin-loaded asymmetric-wettability Janus polydimethylsiloxane wound dressing with surface microstructures is developed via a combined approach involving femtosecond laser technology and template replication. The prepared dressing has a hydrophobic outer surface, which offers antifouling and anticontamination characteristics, and an inner surface featuring groove-like micro/nanostructures with a hydrophilic coating, which collectively improve in vitro NIH/3T3 cell proliferation. Furthermore, the structures significantly increase the loading efficiency of curcumin and decrease its release rate, improving the antibacterial properties of the dressing. In vivo evaluation showed that the dressing effectively accelerates wound healing and epithelial tissue regeneration, achieving a wound healing rate of 95.89% within after 13 days of treatment. This study provides valuable insights into the design and development of drug-loaded Janus wound dressings, which have promising potential for improving wound healing outcomes.

查看原文本刊更多论文

用飞秒激光辅助成型制造姜黄素负载的Janus敷料增强伤口愈合。

创面敷料在临床创面处理中起着至关重要的作用，是修复受损皮肤屏障的重要组成部分。本文采用飞秒激光技术和模板复制相结合的方法，开发了一种具有表面微结构的姜黄素负载的非对称润湿性Janus聚二甲基硅氧烷伤口敷料。制备的敷料具有疏水的外表面，具有防污和防污染的特性，内表面具有具有亲水涂层的沟槽状微/纳米结构，共同提高了体外NIH/3T3细胞的增殖能力。此外，该结构显著提高了姜黄素的负载效率，降低了姜黄素的释放速度，提高了敷料的抗菌性能。体内评价表明，该敷料能有效促进创面愈合和上皮组织再生，治疗13天后创面愈合率达95.89%。该研究为药物负载Janus伤口敷料的设计和开发提供了有价值的见解，该敷料具有改善伤口愈合结果的良好潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.