Nickel(II) Bromide Catalyzed Multicomponent Cyclization to Access 4‐Substituted 2‐Iminothiazolines

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-09-30 DOI:10.1002/ejoc.202500830

Vu H. Luu, Khoa H. D. Nguyen, Kien Q. Truong, Han B. Tran, Hoang V. M. Trinh, Thuy T. Ca, Tung T. Nguyen

引用次数: 0

Abstract

A method is reported which allows for a three‐component cyclization of sulfoxonium ylides, aryl isothiocyanates, and amines to yield 2‐iminothiazolines. The method overcomes the limitation from the scope‐of‐substrate perspective. Success relies on the use of nickel(II) bromide, presumably acting as a Lewis acid catalyst. Investigation of substrate scopes reveals the compatibility of an array of useful functionalities.

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镍（II）溴化催化多组分环化制备4 -取代的2 -亚氨基噻唑类化合物

报道了一种方法，该方法允许三组分环化亚砜酰化，芳基异硫氰酸酯和胺，以产生2 -亚氨基噻唑。该方法克服了从衬底范围角度的限制。成功依赖于溴化镍的使用，可能作为路易斯酸催化剂。对衬底作用域的研究揭示了一系列有用功能的兼容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.