Calcium dynamics in small spaces: lessons learned from modeling in dendritic spines.

IF 3.1 3区生物学 Q2 BIOPHYSICS

Biophysical journal Pub Date : 2025-09-29 DOI:10.1016/j.bpj.2025.09.038

K J McCabe,M Hernández Mesa,P Rangamani

引用次数: 0

Abstract

Spatiotemporal dynamics of calcium regulation in subcellular regions is critical for precise local control of cell signaling. Recent studies have shown that, in addition to biochemical control of localized calcium signaling through buffers and channels, the geometry of the small spaces in which calcium signaling occurs also matters. Geometric organization becomes particularly important when considering the role of organelles such as the mitochondria and endoplasmic reticulum in regulating calcium signaling. Here, we discuss recent advances in our understanding of calcium dynamics in small spaces such as dendritic spines and how computational modeling can reveal a complex interplay between geometry and receptor clustering. We close with other biological examples where such interactions may be important and suggest the possibility of generalizable biophysical principles of localized calcium control.

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小空间中的钙动力学：树突棘建模的经验教训。

亚细胞区域钙调控的时空动态对细胞信号的精确局部控制至关重要。最近的研究表明，除了通过缓冲液和通道对局部钙信号的生化控制外，钙信号发生的小空间的几何形状也很重要。当考虑细胞器（如线粒体和内质网）在调节钙信号传导中的作用时，几何组织变得尤为重要。在这里，我们讨论了我们对小空间（如树突棘）钙动力学的理解的最新进展，以及计算模型如何揭示几何形状和受体聚类之间复杂的相互作用。我们以其他生物例子为例，其中这种相互作用可能是重要的，并提出了局部钙控制的可推广的生物物理原理的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biophysical journal 生物-生物物理

CiteScore

6.10

自引率

5.90%

发文量

3090

审稿时长

2 months

期刊介绍： BJ publishes original articles, letters, and perspectives on important problems in modern biophysics. The papers should be written so as to be of interest to a broad community of biophysicists. BJ welcomes experimental studies that employ quantitative physical approaches for the study of biological systems, including or spanning scales from molecule to whole organism. Experimental studies of a purely descriptive or phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ. Theoretical studies should offer new insights into the understanding ofexperimental results or suggest new experimentally testable hypotheses. Articles reporting significant methodological or technological advances, which have potential to open new areas of biophysical investigation, are also suitable for publication in BJ. Papers describing improvements in accuracy or speed of existing methods or extra detail within methods described previously are not suitable for BJ.