Spatial architecture of development and disease.

IF 52 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2025-09-30 DOI:10.1038/s41576-025-00892-5

Enikő Lázár,Joakim Lundeberg

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引用次数: 0

Abstract

Tissue architecture is a product of a multilayered molecular landscape, where even subtle disruptions in the spatial context can initiate or reflect disease processes. Recent advances in high-throughput spatial omics technologies have enabled the investigation of this complexity in stunning detail, providing groundbreaking insights into how spatial molecular organization shapes health and disease. Spatial analysis empowers the discovery of developmental and disease-associated molecular signatures, cell states and multicellular niches, as well as the evaluation of disease heterogeneity within and across organs. This Review examines spatially resolved pathological molecular alterations in a wide range of disease processes, such as developmental disorders, tumorigenesis, fibrosis and injury responses, neurodegeneration, infection and inflammation, through the lens of these universal biological frameworks. We discuss challenges, opportunities and promising examples in advancing these technologies to clinical applications, including the increasing importance of artificial intelligence. Finally, we explore possible avenues for a more comprehensive, multidimensional assessment of tissues.

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发展和疾病的空间建筑。

组织结构是多层分子景观的产物，即使是空间环境中细微的破坏也可能引发或反映疾病过程。高通量空间组学技术的最新进展使得对这种复杂性的研究能够以惊人的细节进行，为空间分子组织如何塑造健康和疾病提供了开创性的见解。空间分析有助于发现发育和疾病相关的分子特征、细胞状态和多细胞生态位，以及评估器官内和器官间的疾病异质性。本综述通过这些普遍的生物学框架，研究了在广泛的疾病过程中空间解决的病理分子改变，如发育障碍、肿瘤发生、纤维化和损伤反应、神经变性、感染和炎症。我们讨论了将这些技术推进临床应用的挑战、机遇和有希望的例子，包括人工智能日益增长的重要性。最后，我们探讨了对组织进行更全面、多维度评估的可能途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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