Anxiety and Mood Disturbance Are Prospectively Associated With Respiratory Infection Risk and the Mucosal Immune Response to Exercise

IF 3
Sophie E. Harrison, Jason P. Edwards, Ross Roberts, Neil P. Walsh
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Abstract

We prospectively examined whether psychological factors influence (a) respiratory tract infection (RTI) risk and (b) the mucosal immune response to exercise. In Study 1, n = 406 adults (67% male) recorded RTI symptoms for two weeks before and after a marathon. In Study 2, under controlled laboratory conditions, n = 45 adults (51% male) completed 60 min of running at 65% V̇O2peak (EX) and seated rest (CON) in randomised order. Anxiety, total mood disturbance (TMD) and perceived psychological stress were measured before exercise. Saliva collected pre- and post-exercise was analysed for secretory immunoglobulin A (SIgA). Fifty runners suffered an RTI post-marathon. Runners prospectively reporting high trait anxiety or TMD were more likely to suffer an RTI post-marathon (OR [95% CI] = 1.06 [1.02–1.11] and 1.04 [1.01–1.07], respectively). Higher trait anxiety and TMD were associated with a greater reduction in saliva SIgA (p < 0.05). There was no association between mucosal immunity and RTI risk (OR [95% CI] = 1.00 [0.97–1.01]). In Study 2, despite no significant difference between EX and CON (p > 0.05), psychological factors were associated with the SIgA secretion rate response to exercise in men (trait anxiety, state anxiety, TMD, psychological stress: r = −0.55, −0.65, −0.61 and −0.66, respectively; p < 0.01). In conclusion, anxiety and mood disturbance were prospectively associated with infection risk after a marathon and the mucosal immune response to exercise. Athletes should optimise psychological well-being to support immune health. Researchers should take account of psychological factors when examining the mucosal immune response to exercise.

Abstract Image

焦虑和情绪障碍可能与呼吸道感染风险和运动后的粘膜免疫反应相关。
我们前瞻性地研究了心理因素是否会影响(a)呼吸道感染(RTI)风险和(b)运动后的粘膜免疫反应。在研究1中,n = 406名成年人(67%为男性)在马拉松比赛前后两周内记录了RTI症状。在研究2中,在受控的实验室条件下,n = 45名成年人(51%为男性)按随机顺序完成了60分钟的65% V / o峰值(EX)跑步和坐姿休息(CON)。运动前测量焦虑、总情绪障碍(TMD)和感知心理应激。分析运动前和运动后唾液分泌免疫球蛋白A (SIgA)。50名跑步者在马拉松后接受了RTI测试。预期报告高特质焦虑或TMD的跑步者更有可能在马拉松后遭受RTI (or [95% CI]分别= 1.06[1.02-1.11]和1.04[1.01-1.07])。高特质焦虑和TMD与唾液SIgA的降低相关(p < 0.05),心理因素与男性SIgA分泌率对运动的反应相关(特质焦虑、状态焦虑、TMD、心理压力:r = -0.55、-0.65、-0.61和-0.66;p < 0.05)
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