Clinical and Histologic Evidence Documenting the Long-Term Success of Regenerative Therapy Using an Allograft-Biologic Combination.

IF 1.1
Paul S Rosen, Hari Prasad
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Abstract

This retrospective case report documents the successful use of a mineralized allograft hydrated by a combination of recombinant human platelet derived growth factor-BB and enamel matrix derivative to regenerate the buccal furcations of two adjacent maxillary molars. Twelve years later, despite the complete fill with bone in both furcations, the second molar developed a resorptive lesion near the furcation area requiring its removal. The surgical procedure to replace it with a dental implant enabled visual inspection of the furcations on both teeth and histologic evaluation of the second molar's complete furcation fill. The findings from this case present the potential to regenerate a stable new attachment apparatus. The histologic findings further elucidate both the long term fate of this graft-biologic combination which did not completely turnover to host bone as well as the contribution that it may play in guided tissue regenerative therapy.

临床和组织学证据证明使用同种异体移植物-生物联合再生治疗的长期成功。
本回顾性病例报告成功使用重组人血小板衍生生长因子- bb和牙釉质基质衍生物水合的矿化同种异体移植物再生相邻的两颗上颌磨牙的颊功能。12年后,尽管两个分叉处的骨完全填充,但第二磨牙在分叉处附近发生了吸收性损伤,需要将其移除。用种植牙代替原牙的手术过程可以对两颗牙齿的功能进行目视检查,并对第二颗磨牙的完整功能进行组织学评估。这个病例的发现显示了再生一个稳定的新附着装置的潜力。组织学结果进一步阐明了这种移植物-生物组合的长期命运,它没有完全转换到宿主骨,以及它可能在引导组织再生治疗中发挥的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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