Changes in eGFR in adolescent and young adult inpatients receiving nutritional rehabilitation for a restrictive eating disorder: a five-year clinical audit.

IF 4.5 3区 医学 Q2 NUTRITION & DIETETICS
Kirsten Thompson, Elizabeth Kumiko Parker, Michael R Kohn, Anita Stefoska-Needham
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引用次数: 0

Abstract

Background: Impaired renal function may be observed in individuals with a restrictive eating disorder, yet its prevalence and underlying pathophysiological mechanisms are inadequately characterised. The impact of elevated protein intake on estimated glomerular filtration rate (eGFR) in this demographic remains unclear, leading to a lack of specific guidelines regarding protein prescriptions during inpatient treatment. This study describes changes in eGFR as a marker of renal function among adolescents and young adults receiving inpatient care for restrictive eating disorders and evaluates protein prescriptions during nutritional rehabilitation.

Methods: A retrospective audit of adolescent and young adults hospitalised with restrictive eating disorders (2016-2020) on a specialised medical ward was conducted. Data collected included anthropometric measurements, age, serum creatinine, blood urea, energy and protein prescriptions, medical stability upon admission, and hospital length-of-stay. The eGFR was calculated using the CKiDU25 equation. A random intercepts model was employed to assess the relationship between protein intake and eGFR changes during hospitalisation, controlling for confounding variables including age, sex, %mBMI, medical instability, and purging history.

Results: Among the 187 admissions that met inclusion criteria, the mean age was 17.0 ± 1.2 years, 90.9% (n = 170) were females, and mean %mBMI was 80.1 ± 9.5% at admission. Impaired renal function (eGFR < 90 mL/min/1.73 m²) was observed in 35.3% of patients at admission, and 3.2% of patients at discharge. Protein intake increased from 1.9 ± 0.4 g/kg/day on admission to 2.7 ± 0.6 g/kg/day at discharge.

Conclusions: Impaired renal function was observed in approximately one third of this sample of adolescents and young adults hospitalised with restrictive eating disorders and typically resolves during the admission. A high protein prescription of 1.9-2.7 g/kg/day did not deleteriously affect renal function, with eGFR levels improving with nutritional rehabilitation. Prospective studies are needed to confirm the optimal protein prescription during nutritional rehabilitation in patients hospitalised with restrictive eating disorders, and to further explore outcomes in the small subgroup of patients who remain with renal impairment at discharge.

在青少年和年轻成人住院患者接受营养康复的限制性饮食障碍的eGFR的变化:五年临床审计。
背景:在患有限制性饮食障碍的个体中可能观察到肾功能受损,但其患病率和潜在的病理生理机制尚未充分表征。在这一人群中,蛋白质摄入升高对肾小球滤过率(eGFR)的影响尚不清楚,导致住院治疗期间缺乏关于蛋白质处方的具体指南。本研究描述了在接受限制性饮食失调住院治疗的青少年和年轻人中,eGFR作为肾功能标志物的变化,并评估了营养康复期间的蛋白质处方。方法:对2016-2020年在某专科病房因限制性饮食失调住院的青少年和年轻人进行回顾性审计。收集的数据包括人体测量、年龄、血清肌酐、血尿素、能量和蛋白质处方、入院时的医疗稳定性和住院时间。使用CKiDU25方程计算eGFR。采用随机截取模型评估住院期间蛋白质摄入与eGFR变化之间的关系,控制混杂变量包括年龄、性别、mBMI百分比、医疗不稳定性和排空史。结果:187例符合纳入标准的患者中,平均年龄为17.0±1.2岁,女性占90.9% (n = 170),入院时平均mBMI %为80.1±9.5%。肾功能受损(eGFR)结论:大约三分之一的青少年和年轻人因限制性饮食失调住院,肾功能受损,通常在入院期间消退。1.9-2.7 g/kg/天的高蛋白处方对肾功能没有有害影响,eGFR水平随着营养康复而改善。需要前瞻性研究来确认限制性饮食障碍住院患者营养康复期间的最佳蛋白质处方,并进一步探索少数出院时仍存在肾功能损害的患者的预后。
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来源期刊
Journal of Eating Disorders
Journal of Eating Disorders Neuroscience-Behavioral Neuroscience
CiteScore
5.30
自引率
17.10%
发文量
161
审稿时长
16 weeks
期刊介绍: Journal of Eating Disorders is the first open access, peer-reviewed journal publishing leading research in the science and clinical practice of eating disorders. It disseminates research that provides answers to the important issues and key challenges in the field of eating disorders and to facilitate translation of evidence into practice. The journal publishes research on all aspects of eating disorders namely their epidemiology, nature, determinants, neurobiology, prevention, treatment and outcomes. The scope includes, but is not limited to anorexia nervosa, bulimia nervosa, binge eating disorder and other eating disorders. Related areas such as important co-morbidities, obesity, body image, appetite, food and eating are also included. Articles about research methodology and assessment are welcomed where they advance the field of eating disorders.
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