Candida graft arteritis after kidney transplantation: two cases and literature review.

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL

Oxford Medical Case Reports Pub Date : 2025-09-28 eCollection Date: 2025-09-01 DOI:10.1093/omcr/omaf172

Tirlangi Praveen Kumar, Attur Ravindra Prabhu, Pothumarthy Venkata Swathi Kiran, Arun Chawla, P S Priya, Brij Mohan Kumar Singh, Nitin Gupta

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引用次数: 0

Abstract

Background: Candida arteritis of a kidney allograft represents a severe yet rare complication in transplant recipients. Its nonspecific presentation and diagnostic difficulties necessitate a high level of clinical suspicion and a multidisciplinary approach to management.

Case presentation: We report two cases of Candida arteritis in kidney transplant recipients who presented with life-threatening bleeding from the graft anastomotic site shortly after transplantation. Histopathological examination revealed fungal invasion of the arterial walls, with periodic acid-Schiff (PAS) staining demonstrating budding yeast cells and pseudo hyphae. Both patients underwent emergency graft nephrectomy and iliac vessel repair. Antifungal therapy with intravenous fluconazole was initiated. Despite these interventions, one patient succumbed to a rebleed ten days postoperatively, while the other survived but experienced graft loss.

Conclusion: This report highlights the importance of early recognition, maintenance of sterile conditions during organ transport and vigilant postoperative monitoring to minimise the occurrence of this life-threatening complication burden.

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肾移植后假丝酵母移植物动脉炎2例并文献复习。

背景：假丝酵母菌动脉炎在移植肾受者中是一种严重但罕见的并发症。它的非特异性表现和诊断困难需要高水平的临床怀疑和多学科的方法来管理。病例介绍：我们报告了两例肾移植受者的念珠菌动脉炎，他们在移植后不久出现了危及生命的移植吻合口出血。组织病理学检查显示真菌侵袭动脉壁，周期性酸希夫（PAS）染色显示出芽酵母细胞和假菌丝。两例患者均行移植肾切除术及髂血管修复术。开始静脉注射氟康唑抗真菌治疗。尽管采取了这些干预措施，一名患者术后10天再次出血，而另一名患者存活，但经历了移植物丢失。结论：本报告强调了早期识别，器官运输过程中保持无菌条件和术后警惕监测的重要性，以尽量减少这种危及生命的并发症的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oxford Medical Case Reports MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

自引率

0.00%

发文量

125

审稿时长

19 weeks

期刊介绍： Oxford Medical Case Reports (OMCR) is an open access, peer-reviewed online journal publishing original and educationally valuable case reports that expand the field of medicine. The journal covers all medical specialities including cardiology, rheumatology, nephrology, oncology, neurology, and reproduction, comprising a comprehensive resource for physicians in all fields and at all stages of training. Oxford Medical Case Reports deposits all articles in PubMed Central (PMC). Physicians and researchers can find your work through PubMed , helping you reach the widest possible audience. The journal is also indexed in the Web of Science Core Collection . Oxford Medical Case Reports publishes case reports under the following categories: Allergy Audiovestibular medicine Cardiology and cardiovascular systems Critical care medicine Dermatology Emergency medicine Endocrinology and metabolism Gastroenterology and hepatology Geriatrics and gerontology Haematology Immunology Infectious diseases and tropical medicine Medical disorders in pregnancy Medical ophthalmology Nephrology Neurology Oncology Paediatrics Pain Palliative medicine Pharmacology and pharmacy Psychiatry Radiology, nuclear medicine, and medical imaging Respiratory disorders Rheumatology Sexual and reproductive health Sports Medicine Substance abuse.