{"title":"Knowledge, attitudes, and practices regarding chemotherapy-induced bone marrow suppression in ovarian cancer patients.","authors":"Xiaohang Liu, Jiashou Tao","doi":"10.1186/s12957-025-04018-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the knowledge, attitudes, and practices (KAP) of ovarian cancer patients regarding chemotherapy-induced bone marrow suppression.</p><p><strong>Methods: </strong>This cross-sectional study was conducted on ovarian cancer patients at the Hospital between March and October 2024, using a self-designed questionnaire.</p><p><strong>Results: </strong>A total of 505 valid questionnaires were collected, with a 100% valid response rate. The average age of participants was 58.41 ± 6.64 years. The mean KAP and health literacy scores were 20.69 ± 6.24 (possible range: 0-18), 34.69 ± 4.97 (possible range: 10-50), 34.30 ± 7.07 (possible range: 9-45), and 8.18 ± 1.81 (possible range: 3-15), respectively. Pearson's correlation analysis showed positive interrelationships between KAP (r = 0.191, 0.315, P < 0.001), and negative correlations between KAP and health literacy (r=-0.326, -0.100, P < 0.05). Multivariate logistic analysis revealed positive associations of knowledge, attitude, education and cancer stage with practice (OR = 1.079, 4.369, P < 0.05), and negative associations between age and practice (OR = 0.905, 95%CI: 0.869-0.942, P < 0.001). In the adjusted SEM, education was directly associated with knowledge (Estimate = 3.63, P < 0.001). Direct associations were observed among KAP (Estimate = 0.238-0.311, P < 0.001), and between health literacy and knowledge (Estimate=-0.063, P < 0.001) or practice (Estimate=-1.050, P < 0.001).</p><p><strong>Conclusion: </strong>Ovarian cancer patients had sufficient knowledge, moderate attitude, positive practice and poor health literacy towards chemotherapy-induced bone marrow suppression. Educational and behavioral interventions are needed to promote better management of chemotherapy-induced bone marrow suppression.</p>","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"23 1","pages":"351"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482871/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12957-025-04018-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: This study aimed to investigate the knowledge, attitudes, and practices (KAP) of ovarian cancer patients regarding chemotherapy-induced bone marrow suppression.
Methods: This cross-sectional study was conducted on ovarian cancer patients at the Hospital between March and October 2024, using a self-designed questionnaire.
Results: A total of 505 valid questionnaires were collected, with a 100% valid response rate. The average age of participants was 58.41 ± 6.64 years. The mean KAP and health literacy scores were 20.69 ± 6.24 (possible range: 0-18), 34.69 ± 4.97 (possible range: 10-50), 34.30 ± 7.07 (possible range: 9-45), and 8.18 ± 1.81 (possible range: 3-15), respectively. Pearson's correlation analysis showed positive interrelationships between KAP (r = 0.191, 0.315, P < 0.001), and negative correlations between KAP and health literacy (r=-0.326, -0.100, P < 0.05). Multivariate logistic analysis revealed positive associations of knowledge, attitude, education and cancer stage with practice (OR = 1.079, 4.369, P < 0.05), and negative associations between age and practice (OR = 0.905, 95%CI: 0.869-0.942, P < 0.001). In the adjusted SEM, education was directly associated with knowledge (Estimate = 3.63, P < 0.001). Direct associations were observed among KAP (Estimate = 0.238-0.311, P < 0.001), and between health literacy and knowledge (Estimate=-0.063, P < 0.001) or practice (Estimate=-1.050, P < 0.001).
Conclusion: Ovarian cancer patients had sufficient knowledge, moderate attitude, positive practice and poor health literacy towards chemotherapy-induced bone marrow suppression. Educational and behavioral interventions are needed to promote better management of chemotherapy-induced bone marrow suppression.
期刊介绍：
World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics.
Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.
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