Health and Development of Children Born Moderate and Late Preterm and Early Term at Age 10 in French Birth Cohorts ELFE and EPIPAGE 2.

IF 2.5 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Paediatric and perinatal epidemiology Pub Date : 2025-09-29 DOI:10.1111/ppe.70069

Laura Pavicic, Laetitia Marchand-Martin, Ayoub Mitha, Marie-Noelle Dufourg, Véronique Pierrat, Valérie Benhammou, Marie-Aline Charles, Pierre-Yves Ancel

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引用次数: 0

Abstract

Background: Lower gestational age (GA) is linked to higher mortality and morbidity. Long-term health and developmental difficulties of individuals born moderate (MPT, 32-33 GA) and late (LPT, 34-36 GA) preterm, and early term (ET, 37-38 GA) are less explored than those of their very preterm peers.

Objectives: To test how being born MPT, LPT, or ET affects health and development at age 10, compared to full-term (FT, 39-40 GA) births.

Methods: Data from two ongoing French nationwide birth cohorts, initiated in 2011, were collected at 10 years via telephone interview (n = 8372) and home visit (n = 6418). Weighting procedures accounted for study design, non-inclusion, and participation. Outcome-wide regressions (modified Poisson, linear), adjusted for socioeconomic situation and pregnancy complications, were used to calculate adjusted relative risks (aRR) and beta-coefficients (β).

Results: No increased risk of asthma/atopy was observed for our MPT, LPT, and ET populations, except for allergic rhinitis in MPT. Strabismus was more prevalent among MPT, LPT, and ET (2.3%-3.0%) than FT (1.3%), corresponding to aRR of 1.99 (95% CI 0.91, 4.39), 1.67 (95% CI 0.85, 3.28), and 2.18 (95% CI 1.37, 3.47), respectively. MPT and LPT had increased risk of balance problems, with aRR of 1.63 (95% CI 0.81, 3.32) and 1.80 (95% CI 1.14, 2.82), respectively. MPT scored on average lower on the WISC-V full-scale IQ Matrix β = -0.6 (95% CI -1.17, -0.11) and performance IQ Puzzle β = -0.7 (95% CI -1.23, -0.26) subtests, compared to FT, and had an increased risk of dental malposition, aRR = 1.42 (95% CI 1.15, 1.75).

Conclusions: While most outcomes (respiratory, anthropometry, cardiometabolic) did not differ between MPT, LPT, ET, and their FT peers, others, including strabismus, were more prevalent among preterm and ET. Some outcomes were specific to MPT, including lower WISC-V average scores and dental issues.

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法国出生队列ELFE和EPIPAGE中10岁中度、晚期早产和早期早产儿童的健康与发育

背景：低胎龄（GA）与较高的死亡率和发病率有关。中度早产儿（MPT, 32-33 GA）、晚期早产儿（LPT, 34-36 GA）和早期早产儿（ET, 37-38 GA）的长期健康和发育困难较少被研究。目的：检测与足月出生（足月出生，39-40 GA）相比，MPT、LPT或ET出生对10岁儿童健康和发育的影响。方法：通过电话访谈（n = 8372）和家访（n = 6418）收集2011年开始的两个正在进行的法国全国出生队列的10年数据。加权程序考虑了研究设计、未纳入和参与。采用全结果回归（修正泊松线性），对社会经济状况和妊娠并发症进行校正，计算校正相对危险度（aRR）和β系数（β）。结果：除了MPT患者的变应性鼻炎外，MPT、LPT和ET人群的哮喘/特应性风险均未增加。MPT、LPT和ET的斜视发生率（2.3%-3.0%）高于FT(1.3%)，相应的aRR分别为1.99 （95% CI 0.91, 4.39）、1.67 （95% CI 0.85, 3.28）和2.18 （95% CI 1.37, 3.47）。MPT和LPT的平衡问题风险增加，aRR分别为1.63 （95% CI 0.81, 3.32）和1.80 （95% CI 1.14, 2.82）。与FT相比，MPT在WISC-V全面智商矩阵β = -0.6 （95% CI -1.17, -0.11）和性能智商谜题β = -0.7 （95% CI -1.23, -0.26）亚测试中的平均得分较低，并且牙位失调的风险增加，aRR = 1.42 （95% CI 1.15, 1.75）。结论：虽然MPT、LPT、ET和他们的FT同伴之间的大多数结果（呼吸、人体测量、心脏代谢）没有差异，但其他结果，包括斜视，在早产儿和ET中更为普遍。一些结果是MPT特有的，包括较低的WISC-V平均评分和牙齿问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Paediatric and perinatal epidemiology 医学-妇产科学

CiteScore

5.40

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Paediatric and Perinatal Epidemiology crosses the boundaries between the epidemiologist and the paediatrician, obstetrician or specialist in child health, ensuring that important paediatric and perinatal studies reach those clinicians for whom the results are especially relevant. In addition to original research articles, the Journal also includes commentaries, book reviews and annotations.