Dual role of dietary tryptophan on memory regulation in male albino wistar rats - synergistic modulation of serotonergic signaling and kynurenine pathway.

IF 3.6 4区医学 Q2 NEUROSCIENCES

Nutritional Neuroscience Pub Date : 2025-09-29 DOI:10.1080/1028415X.2025.2565703

Huma Ikram, Shahla Perveen, Darakhshan J Haleem

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引用次数: 0

Abstract

Objective: This study investigates the impact of tryptophan metabolism on synaptic plasticity, neurogenesis, and memory consolidation using a combined biochemical and behavioral approach.

Methods: We treated male Albino Wistar rats with different doses of tryptophan for 4 weeks followed by weekly assessment of memory performance through Morris Water Maze (MWM) and Novel Object Recognition (NOR) tests. High-performance liquid chromatography (HPLC) was used to quantify serotonin and metabolites in hippocampus, while kynurenine in plasma samples.

Results: Our findings reveal that low dose of tryptophan improved learning and memory in rats while high dose significantly impaired spatial and recognition memory, correlating with reduced serotonin and increased kynurenic acid levels. Conversely, tryptophan supplementation at high dose was also accompanied by increased Interleukin-6 (IL-6), Interleukin-1β (IL-1β) and Tumor Necrosis Factor-α (TNF-α) expression in brain.

Discussion: These results highlight the dual role of tryptophan in memory regulation - through serotonergic signaling and kynurenine pathway modulation - providing potential therapeutic targets for memory-related disorders such as Alzheimer's and Parkinson's-related dementia.

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膳食色氨酸在雄性白化wistar大鼠记忆调节中的双重作用——血清素能信号和犬尿氨酸途径的协同调节。

目的：研究色氨酸代谢对突触可塑性、神经发生和记忆巩固的影响。方法：用不同剂量色氨酸治疗雄性白化Wistar大鼠4周，每周通过Morris水迷宫（MWM）和新物体识别（NOR）测试评估记忆表现。采用高效液相色谱法（HPLC）定量海马中血清素及其代谢物和血浆样品中的犬尿氨酸。结果：低剂量色氨酸可改善大鼠的学习记忆能力，而高剂量色氨酸可显著损害大鼠的空间记忆和识别记忆能力，这与血清素水平降低和犬尿酸水平升高有关。相反，高剂量补充色氨酸还伴随着脑内白细胞介素-6 （IL-6）、白细胞介素-1β (IL-1β)和肿瘤坏死因子-α (TNF-α)表达的增加。讨论：这些结果强调了色氨酸在记忆调节中的双重作用——通过血清素能信号和犬尿氨酸途径调节——为阿尔茨海默氏症和帕金森相关痴呆等记忆相关疾病提供了潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.