Soerajja Bhoelan, Serife Kürül, Charlotte G Krol, Dominque van Midden, Rene Bakker
{"title":"L-Glutamine-Induced Acute Kidney Injury: A Clinical Observation.","authors":"Soerajja Bhoelan, Serife Kürül, Charlotte G Krol, Dominque van Midden, Rene Bakker","doi":"10.1159/000548247","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>L-Glutamine is increasingly used as a dietary supplement and its use is, as is the case with other amino acids, considered safe. L-Glutamine is the most abundant amino acid in the human body and is involved in many metabolic reactions. Within the kidney L-Glutamine has an important role in the generation of ammonia and bicarbonate.</p><p><strong>Case presentation: </strong>We report a case of acute kidney injury (AKI) as a result of tubular damage in a patient who used 18 grams of L-Glutamine on a daily basis. Possible mechanisms are proposed of which increased single nephron ammonia production and toxicity seems most likely cause of AKI.</p><p><strong>Conclusion: </strong>We advise cautious use of L-Glutamine supplements in elderly patient with an already compromised kidney function.</p>","PeriodicalId":18998,"journal":{"name":"Nephron","volume":" ","pages":"47-51"},"PeriodicalIF":2.3000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nephron","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000548247","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/29 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: L-Glutamine is increasingly used as a dietary supplement and its use is, as is the case with other amino acids, considered safe. L-Glutamine is the most abundant amino acid in the human body and is involved in many metabolic reactions. Within the kidney L-Glutamine has an important role in the generation of ammonia and bicarbonate.
Case presentation: We report a case of acute kidney injury (AKI) as a result of tubular damage in a patient who used 18 grams of L-Glutamine on a daily basis. Possible mechanisms are proposed of which increased single nephron ammonia production and toxicity seems most likely cause of AKI.
Conclusion: We advise cautious use of L-Glutamine supplements in elderly patient with an already compromised kidney function.
期刊介绍：
''Nephron'' comprises three sections, which are each under the editorship of internationally recognized leaders and served by specialized Associate Editors. Apart from high-quality original research, ''Nephron'' publishes invited reviews/minireviews on up-to-date topics. Papers undergo an innovative and transparent peer review process encompassing a Presentation Report which assesses and summarizes the presentation of the paper in an unbiased and standardized way.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
