{"title":"A Green Method for Seized Drug Screening Using a Portable Liquid Chromatograph With UV-LED Detection","authors":"Jayda Barber, Ira S. Lurie","doi":"10.1002/jssc.70276","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Portable instruments allow for on-site real-time analyses and generally take up less resources compared to standard-sized instruments. In this project, we tested the suitability of a portable liquid chromatograph for seized drug screening and how it, alone, may fulfill the requirements set forth by the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG). For this study, we used a portable liquid chromatograph, which employed a dual column system with on-column dual UV-LED detection. All 16 drugs representing different drug classes could be identified by a combination of dual relative retention times and dual UV absorbance ratios. Most classical drugs, which represent non-novel psychoactive compounds, could be identified based on the SWGDRUG guidelines. These results suggest the potential for liquid chromatography to be performed in the field using portable devices and to provide a greener alternative to traditional liquid chromatography due to greatly reduced solvent consumption.</p>\n </div>","PeriodicalId":17098,"journal":{"name":"Journal of separation science","volume":"48 10","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of separation science","FirstCategoryId":"5","ListUrlMain":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.70276","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Portable instruments allow for on-site real-time analyses and generally take up less resources compared to standard-sized instruments. In this project, we tested the suitability of a portable liquid chromatograph for seized drug screening and how it, alone, may fulfill the requirements set forth by the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG). For this study, we used a portable liquid chromatograph, which employed a dual column system with on-column dual UV-LED detection. All 16 drugs representing different drug classes could be identified by a combination of dual relative retention times and dual UV absorbance ratios. Most classical drugs, which represent non-novel psychoactive compounds, could be identified based on the SWGDRUG guidelines. These results suggest the potential for liquid chromatography to be performed in the field using portable devices and to provide a greener alternative to traditional liquid chromatography due to greatly reduced solvent consumption.
期刊介绍：
The Journal of Separation Science (JSS) is the most comprehensive source in separation science, since it covers all areas of chromatographic and electrophoretic separation methods in theory and practice, both in the analytical and in the preparative mode, solid phase extraction, sample preparation, and related techniques. Manuscripts on methodological or instrumental developments, including detection aspects, in particular mass spectrometry, as well as on innovative applications will also be published. Manuscripts on hyphenation, automation, and miniaturization are particularly welcome. Pre- and post-separation facets of a total analysis may be covered as well as the underlying logic of the development or application of a method.
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