Mitochondrial adaptations from heat acclimation - A narrative review.

IF 2.9 2区 生物学 Q2 BIOLOGY
Marcos S Keefe, Danielle E Levitt, Heather L Vellers, Courteney L Benjamin, Yasuki Sekiguchi
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引用次数: 0

Abstract

In recent decades, global temperature and humidity levels have surged. These increases in temperature and humidity are associated with higher risk of heat-related illnesses and impaired exercise performance, thereby prompting investigation into physiological responses to heat stress. Preconditioning strategies, including heat acclimation/acclimatization (HA), elicit physiological adaptations to enhance response to future heat exposures. Within HA research, an area of growing interest is examination of subcellular adaptations that contribute to whole-body acclimation, such as changes to/within mitochondria. External heat stress alters molecular pathways involved in mitochondrial biogenesis and bioenergetic function, but the relationship between these alterations and whole-body HA adaptations remains relatively unknown. Therefore, this review provides a detailed examination of the impact of HA on mitochondria across cell models, rodent models, and humans, linking these changes to exercise performance. Based on the current evidence, we propose a HA protocol aimed at promoting mitochondrial adaptations while maximizing traditional HA benefits. Lastly, we identify key areas for future research to further explore and enhance our understanding of mitochondrial responses to HA.

热驯化对线粒体的适应性——述评。
近几十年来,全球气温和湿度急剧上升。温度和湿度的增加与热相关疾病的高风险和运动表现受损有关,因此促使人们对热应激的生理反应进行研究。预适应策略,包括热驯化/驯化(HA),引发生理适应,以增强对未来热暴露的反应。在透明质酸研究中,一个越来越受关注的领域是对亚细胞适应的研究,亚细胞适应有助于全身适应,例如线粒体的变化。外部热应激改变了参与线粒体生物发生和生物能量功能的分子途径,但这些改变与全身HA适应之间的关系仍然相对未知。因此,本综述详细研究了透明质酸对细胞模型、啮齿动物模型和人类线粒体的影响,并将这些变化与运动表现联系起来。基于目前的证据,我们提出了一个旨在促进线粒体适应的HA协议,同时最大化传统HA的好处。最后,我们确定了未来研究的关键领域,以进一步探索和提高我们对HA的线粒体反应的理解。
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来源期刊
Journal of thermal biology
Journal of thermal biology 生物-动物学
CiteScore
5.30
自引率
7.40%
发文量
196
审稿时长
14.5 weeks
期刊介绍: The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are: • The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature • The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature • Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause • Effects of temperature on reproduction and development, growth, ageing and life-span • Studies on modelling heat transfer between organisms and their environment • The contributions of temperature to effects of climate change on animal species and man • Studies of conservation biology and physiology related to temperature • Behavioural and physiological regulation of body temperature including its pathophysiology and fever • Medical applications of hypo- and hyperthermia Article types: • Original articles • Review articles
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