Helicobacter pylori infection is associated with an increased risk of chronic obstructive pulmonary disease and asthma.

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pathogens Pub Date : 2025-09-29 DOI:10.1186/s13099-025-00754-9

Chiwook Chung, Kyu Na Lee, Kyungdo Han, Dong Wook Shin, Sei Won Lee

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引用次数: 0

Abstract

Background: Helicobacter pylori infection, commonly observed in peptic ulcers, induces chronic systemic inflammation. Chronic obstructive pulmonary disease (COPD) and asthma are inflammatory airway diseases. We investigated the association of H. pylori infection with COPD and asthma.

Methods: Data from individuals who underwent H. pylori eradication treatment between 2009 and 2017 were obtained from the Korean National Health Insurance Database. In total, 33,017 individuals aged ≥ 40 years with H. pylori infection and 168,524 matched controls were identified and monitored until December 2019. Multivariate Cox proportional hazards models were used to estimate the adjusted hazard ratios (aHR) for risk factors associated with COPD and asthma.

Results: The incidences of COPD and asthma among individuals with H. pylori infection were 10.92/1,000 person-years and 15.99/1,000 person-years, respectively. The risk of developing COPD (aHR 1.13, 95% confidence interval [CI] 1.08-1.19) and asthma (aHR 1.17, 95% CI 1.12-1.22) was higher among individuals with H. pylori infection, even after adjusting for smoking status. Subgroup analysis revealed that the risk of COPD was more pronounced among older adults (≥ 65 years) and current smokers. In contrast, the risk for asthma did not differ according to age or smoking status.

Conclusions: H. pylori infection is associated with an increased risk of COPD and asthma. The risk of asthma was consistent across age groups and smoking statuses; in contrast, the risk of COPD varied. The findings of the present study underscore the pathophysiological interactions between chronic inflammation in the stomach and the lungs.

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幽门螺杆菌感染与慢性阻塞性肺病和哮喘的风险增加有关。

背景：幽门螺杆菌感染，常见于消化性溃疡，可引起慢性全身性炎症。慢性阻塞性肺疾病（COPD）和哮喘是炎症性气道疾病。我们调查了幽门螺杆菌感染与COPD和哮喘的关系。方法：2009年至2017年接受幽门螺杆菌根除治疗的个体数据来自韩国国民健康保险数据库。截至2019年12月，共有33,017名年龄≥40岁的幽门螺杆菌感染患者和168,524名匹配的对照组被确定并监测。使用多变量Cox比例风险模型来估计COPD和哮喘相关危险因素的调整风险比（aHR）。结果：幽门螺杆菌感染个体COPD和哮喘的发病率分别为10.92/ 1000人年和15.99/ 1000人年。即使在调整吸烟状况后，幽门螺杆菌感染个体发生COPD （aHR 1.13, 95%可信区间[CI] 1.08-1.19）和哮喘（aHR 1.17, 95%可信区间[CI] 1.12-1.22）的风险更高。亚组分析显示，COPD的风险在老年人（≥65岁）和当前吸烟者中更为明显。相比之下，患哮喘的风险并不因年龄或吸烟状况而有所不同。结论：幽门螺杆菌感染与COPD和哮喘风险增加有关。哮喘的风险在不同年龄组和吸烟状况之间是一致的；相反，患慢性阻塞性肺病的风险各不相同。本研究的发现强调了胃和肺慢性炎症之间的病理生理相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).