Association between mean corpuscular hemoglobin concentration and mortality in ICU patients with acute kidney injury: a retrospective multicenter cohort study.

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-09-29 DOI:10.1186/s40001-025-03186-y

Sheng Chen, Xuejin Ye, Lin Guo, Xiaohan Ma, Lingling Wu, Yiwen Li, Minsheng Wu, Rong Tang, Ting Zhang, Peng Jiang, Hongjun Gao, Minghe Jiang

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引用次数: 0

Abstract

Background: The prognostic value of mean corpuscular hemoglobin concentration (MCHC) in ICU patients with acute kidney injury (AKI) is unclear.

Methods: We performed a retrospective multicenter cohort study using MIMIC-IV and eICU-CRD. Adults with AKI and an admission MCHC (first 24 h) were included. Outcomes were 30-and 90-day in-hospital mortality. Survival was compared across MCHC quartiles, and Cox models (with restricted cubic splines) estimated adjusted associations.

Results: Among 111,817 patients (MIMIC-IV n = 54,422; eICU-CRD n = 57,395), higher MCHC was associated with lower mortality. Survival differed across MCHC quartiles (log-rank p < 0.0001 in both cohorts). In adjusted models, the highest vs. lowest MCHC quartile had a lower risk of death (MIMIC-IV HR 0.65, 95% CI 0.60-0.70; eICU-CRD HR 0.62, 95% CI 0.58-0.66). Spline analyses suggested a nonlinear association in MIMIC-IV and an approximately linear association in eICU-CRD.

Conclusions: Admission MCHC was associated with 30-and 90-day mortality in ICU patients with AKI across two large databases. MCHC may aid risk stratification in this population.

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ICU急性肾损伤患者平均红细胞血红蛋白浓度与死亡率的关系：一项回顾性多中心队列研究

背景：平均红细胞血红蛋白浓度（MCHC）在ICU急性肾损伤（AKI）患者中的预后价值尚不清楚。方法：我们使用MIMIC-IV和eICU-CRD进行了一项回顾性多中心队列研究。纳入了AKI和入院前24小时MCHC的成人。结果是30天和90天的住院死亡率。比较MCHC四分位数的生存率，并用Cox模型（限制三次样条）估计调整后的相关性。结果：在111,817例患者中（MIMIC-IV n = 54,422; eICU-CRD n = 57,395），较高的MCHC与较低的死亡率相关。结论：在两个大型数据库中，入院时MCHC与AKI ICU患者的30天和90天死亡率相关。妇幼健康检查可能有助于这一人群的风险分层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.