Age and sex but not disease activity or duration are associated with muscle mass in paediatric Crohn's disease.

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-09-27 DOI:10.1016/j.clnesp.2025.09.025

Bayan Aljilani, Kaung Yan, Iyad Naim, Ana-Maria Darie, Mustafa Agbna, Muhammad H K Bahrin, Kostas Tsintzas, Gordon W Moran

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引用次数: 0

Abstract

Background: There is evidence of low muscle mass in adults with active Crohn's disease (CD) compared to patients in remission, but this has not been explored in paediatric CD.

Aim: To assess the psoas muscle cross sectional area (PCSA) measured using magnetic resonance enterography (MRE) in paediatric CD patients and compare this between those with active or inactive disease.

Design: Paediatric CD patients who underwent MRE during 2016 to 2023 were included. Muscle mass was measured as PCSA at the right and left area of psoas muscle at the upper level of Lumbar 3 (L3) vertebra. Disease activity was defined by a clinical radiologist based on MRE images. Bivariable regression was used to explore unadjusted relationships, whereas a multiple linear regression model was constructed to adjust for potential confounders (disease activity, sex, age at MRE, disease duration, and current biologic use).

Results: 107 patients with CD (57.9% males) aged 13.0 (11.0, 15.0) [median (interquartile range)] were included. Most patients (64.5%) had active disease and the median disease duration for the whole cohort was 0.97 (0.49, 3.07) years. There was no difference in PCSA between patients with active or inactive disease [25.06 (19.51, 33.99) and 26.51 (20.62, 36.99) cm², respectively]. After adjusting for all covariates, the multivariable model identified sex and age at MRE as significant predictors of PCSA. Males had a 6.72 cm² (-11.19, -2.25cm²; p=0.004) higher PCSA compared to females. For every 1-year increase in age, PCSA increased by 2.92 cm² (2.04, 3.81; p<0.001), adjusting for other covariates. Disease activity (p= 0.22), disease duration (p= 0.49) and current biologic use (p= 0.94) did not show significant associations with PCSA.

Conclusion: Age and sex but not disease activity or duration are significantly associated with muscle mass as measured by PCSA in paediatric CD.

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儿童克罗恩病的肌肉质量与年龄和性别有关，但与疾病活动或病程无关。

背景：有证据表明，成人活动性克罗恩病（CD）患者与缓解期患者相比，肌肉质量较低，但尚未在儿科克罗恩病中进行研究。目的：评估儿童克罗恩病患者使用磁共振肠图（MRE）测量的腰肌横截面积（PCSA），并比较活动性和非活动性疾病患者之间的差异。设计：纳入2016年至2023年期间接受MRE治疗的儿科CD患者。采用PCSA测量腰3 （L3）椎体上水平左右腰肌区域的肌肉质量。疾病活动度由临床放射科医生根据MRE图像确定。使用双变量回归来探索未调整的关系，而构建多元线性回归模型来调整潜在的混杂因素（疾病活动性、性别、MRE时的年龄、疾病持续时间和当前的生物使用）。结果：纳入107例CD患者（57.9%为男性），年龄13.0(11.0,15.0)[中位数（四分位数间距）]。大多数患者（64.5%）有活动性疾病，整个队列的中位疾病持续时间为0.97（0.49,3.07）年。活动性和非活动性病变患者的PCSA无差异[分别为25.06（19.51,33.99）和26.51 (20.62,36.99)cm2]。在调整了所有协变量后，多变量模型确定了性别和年龄在MRE是PCSA的显著预测因子。男性的PCSA比女性高6.72 cm2 （-11.19, -2.25cm2; p=0.004）。年龄每增加1年，PCSA增加2.92 cm2（2.04, 3.81）。结论：年龄和性别与儿童CD患者PCSA测量的肌肉质量显著相关，但与疾病活动度或病程无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.