Interaction between toll-like receptor 4 polymorphism and abdominal obesity on ovarian cancer risk in Chinese women.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

BMC Women's Health Pub Date : 2025-09-29 DOI:10.1186/s12905-025-04001-w

Jiamin Zhu, Baixia Yang, Xiaogang Zhai, Feng Ni, Dan Tao, Cheng Tan

{"title":"Interaction between toll-like receptor 4 polymorphism and abdominal obesity on ovarian cancer risk in Chinese women.","authors":"Jiamin Zhu, Baixia Yang, Xiaogang Zhai, Feng Ni, Dan Tao, Cheng Tan","doi":"10.1186/s12905-025-04001-w","DOIUrl":null,"url":null,"abstract":"Objectives: the aim of this study was to evaluate the impact of TLR4 gene single nucleotide polymorphisms (SNPs) and additional TLR4 gene SNP- SNP and SNP- abdominal obesity (AO) interaction on ovarian cancer (OC) risk.Methods: Generalized multifactor dimensionality reduction method were utilized to identify the most informative interactions between four SNPs in the TLR4 gene and abdominal obesity. Logistic regression was employed to investigate the association between 4 SNPs within TLR4 gene and OC risk, and additional SNP- SNP and gene- AO interaction on OC risk, ORs (95%CI) were calculated.Results: The analysis of logistic regression indicated a markedly elevated risk of OC in individuals carrying either the rs4986790-G or rs11536889-C alleles in the TLR4 gene compared to those with the standard genetic variations, adjusted ORs (95%CI) were 1.61 (1.28-1.96) and 1.48 (1.09-1.91). GMDR analysis indicated a significant two-locus model (p = 0.018) involving rs4986790 and rs11536889, and a significant two-locus model (p = 0.001) involving rs4986790 and AO. Participants with rs4986790- AG/GG and rs11536889GC/ CC genotype has the highest OC risk, compared to participants with rs4986790-AA and rs11536889-GG genotype, OR (95%CI) = 2.58 (1.46-3.71), and abdominal obese participants with rs4986790- AG/GG genotype have the highest OC risk, compared to non- abdominal obese participants with rs4986790-AA genotype, OR (95%CI) = 3.17 (1.78-4.58).Conclusions: The findings suggested that TLR4 gene rs4986790 and rs11536889 polymorphisms were associated with increased OC risk. Significant interaction also existed between rs4986790 and AO, which means that the WC levels may influence the impact of rs4986790 on OC risk.","PeriodicalId":9204,"journal":{"name":"BMC Women's Health","volume":"25 1","pages":"452"},"PeriodicalIF":2.7000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481797/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Women's Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12905-025-04001-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: the aim of this study was to evaluate the impact of TLR4 gene single nucleotide polymorphisms (SNPs) and additional TLR4 gene SNP- SNP and SNP- abdominal obesity (AO) interaction on ovarian cancer (OC) risk.

Methods: Generalized multifactor dimensionality reduction method were utilized to identify the most informative interactions between four SNPs in the TLR4 gene and abdominal obesity. Logistic regression was employed to investigate the association between 4 SNPs within TLR4 gene and OC risk, and additional SNP- SNP and gene- AO interaction on OC risk, ORs (95%CI) were calculated.

Results: The analysis of logistic regression indicated a markedly elevated risk of OC in individuals carrying either the rs4986790-G or rs11536889-C alleles in the TLR4 gene compared to those with the standard genetic variations, adjusted ORs (95%CI) were 1.61 (1.28-1.96) and 1.48 (1.09-1.91). GMDR analysis indicated a significant two-locus model (p = 0.018) involving rs4986790 and rs11536889, and a significant two-locus model (p = 0.001) involving rs4986790 and AO. Participants with rs4986790- AG/GG and rs11536889GC/ CC genotype has the highest OC risk, compared to participants with rs4986790-AA and rs11536889-GG genotype, OR (95%CI) = 2.58 (1.46-3.71), and abdominal obese participants with rs4986790- AG/GG genotype have the highest OC risk, compared to non- abdominal obese participants with rs4986790-AA genotype, OR (95%CI) = 3.17 (1.78-4.58).

Conclusions: The findings suggested that TLR4 gene rs4986790 and rs11536889 polymorphisms were associated with increased OC risk. Significant interaction also existed between rs4986790 and AO, which means that the WC levels may influence the impact of rs4986790 on OC risk.

查看原文本刊更多论文

toll样受体4多态性与腹部肥胖对中国女性卵巢癌风险的相互作用

目的：本研究的目的是评估TLR4基因单核苷酸多态性（SNP）和额外的TLR4基因SNP- SNP和SNP-腹部肥胖（AO）相互作用对卵巢癌（OC）风险的影响。方法：采用广义多因素降维方法，确定TLR4基因中4个snp与腹部肥胖之间最具信息量的相互作用。采用Logistic回归分析TLR4基因内4个SNP与OC风险的相关性，并计算额外的SNP- SNP和基因- AO相互作用对OC风险的or （95%CI）。结果：logistic回归分析显示，携带TLR4基因rs4986790-G或rs11536889-C等位基因的个体与携带标准遗传变异的个体相比，患OC的风险显著升高，调整后的or （95%CI）分别为1.61（1.28-1.96）和1.48（1.09-1.91）。GMDR分析显示rs4986790和rs11536889存在显著的双位点模型（p = 0.018）， rs4986790和AO存在显著的双位点模型（p = 0.001）。与rs4986790- AG/GG和rs11536889GC/ CC基因型的参与者相比，rs4986790- aa和rs11536889-GG基因型的参与者有最高的OC风险，OR (95%CI) = 2.58(1.46-3.71)；与rs4986790- AG/GG基因型的非腹部肥胖参与者相比，rs4986790- AG/GG基因型的参与者有最高的OC风险，OR (95%CI) = 3.17（1.78-4.58）。结论：研究结果提示TLR4基因rs4986790和rs11536889多态性与OC风险增加相关。rs4986790与AO之间也存在显著交互作用，说明WC水平可能影响rs4986790对OC风险的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.40

自引率

4.00%

发文量

444

审稿时长

>12 weeks

期刊介绍： BMC Women''s Health is an open access, peer-reviewed journal that considers articles on all aspects of the health and wellbeing of adolescent girls and women, with a particular focus on the physical, mental, and emotional health of women in developed and developing nations. The journal welcomes submissions on women''s public health issues, health behaviours, breast cancer, gynecological diseases, mental health and health promotion.