Effect of vitamin D and E supplementation on pain relief and premenstrual symptoms in primary dysmenorrhea: a randomized controlled trial.

IF 2.7 3区医学 Q2 OBSTETRICS & GYNECOLOGY

BMC Women's Health Pub Date : 2025-09-29 DOI:10.1186/s12905-025-04007-4

Maryam Sadat Hosseini, Maryam Talayeh, Alireza Haghbin Toutounchi, Afsaneh Hosseini, Nesa Moradi, Saeideh Iranshahi, Fatemeh Abdollahi Aliabadi

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引用次数: 0

Abstract

Introduction: Primary dysmenorrhea is a common condition characterized by painful menstrual cramps. Vitamin D and E are suggested to have potential benefits in managing dysmenorrhea. This study aimed to investigate the effects of vitamin D and E supplements combination on pain intensity and premenstrual symptoms in individuals with primary dysmenorrhea.

Methods: A double blinded randomized controlled trial was conducted with 106 participants diagnosed with primary dysmenorrhea. The participants were randomly assigned to either the intervention group (received vitamin D and E supplements) or the control group (received placebo). Pain intensity and premenstrual symptoms were assessed at baseline and after four months of supplementation.

Results: The intervention group exhibited a significant reduction in pain intensity (NPRS: from 7.85 ± 1.15 to 3.75 ± 1.40; mean difference - 4.10, 95% CI: -4.61 to -3.58, p < 0.001) compared to controls (7.68 ± 1.20 to 6.02 ± 1.70). Premenstrual symptoms significantly improved (PMS score: 32.42 ± 4.67 to 9.02 ± 8.84, Δ=-23.40, 95% CI: -26.51 to -21.02, p < 0.001). Baseline vitamin D inversely correlated with pain (r=-0.768, p = 0.001).

Conclusion: Combined vitamin D and E supplementation significantly reduces pain and PMS in vitamin D-deficient women. Healthcare providers may consider this regimen for dysmenorrhea management, pending further optimization studies.

Trial registration: In IRCT.ir with number IRCT20220720055506N1 at 2023-02-01.

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补充维生素D和E对原发性痛经患者疼痛缓解和经前症状的影响：一项随机对照试验

简介：原发性痛经是一种以痛经为特征的常见疾病。维生素D和E被认为对治疗痛经有潜在的好处。本研究旨在探讨维生素D和E补充剂组合对原发性痛经患者疼痛强度和经前症状的影响。方法：对106例原发性痛经患者进行双盲随机对照试验。参与者被随机分配到干预组（接受维生素D和E补充剂）或对照组（接受安慰剂）。在基线和补充4个月后评估疼痛强度和经前症状。结果：干预组疼痛强度显著降低（NPRS：从7.85±1.15降至3.75±1.40；平均差值- 4.10,95% CI: -4.61至-3.58,p）。结论：维生素D和E联合补充可显著减轻维生素D缺乏症妇女的疼痛和经前综合症。医疗保健提供者可能会考虑这种方案的痛经管理，等待进一步的优化研究。试验注册：在IRCT。IRCT20220720055506N1，编号2023-02-01。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.40

自引率

4.00%

发文量

444

审稿时长

>12 weeks

期刊介绍： BMC Women''s Health is an open access, peer-reviewed journal that considers articles on all aspects of the health and wellbeing of adolescent girls and women, with a particular focus on the physical, mental, and emotional health of women in developed and developing nations. The journal welcomes submissions on women''s public health issues, health behaviours, breast cancer, gynecological diseases, mental health and health promotion.